1. Objective a. Objective. The Nonhuman Primate Contraceptive Core (NPCC) will provide services and coordination of animal usage for U54 Contraceptive Center investigators with approved projects. The NPCC maintains a pool of cynomolgus macaque females and males available for contraceptive (mating) trials in the Division of Animal Resources (DAR), ONPRC;coordinates and performs studies on potential contraceptive agents;takes vaginal swabs to confirm menstruation and insure mating has occurred;performs ultrasounds to monitor for pregnancies;obtains blood samples for hormone assays, pharmacokinetic studies and metabolic profiles. The Core acclimates the females to a small group (harem) housing situations (10 females to one male) wherein they can be separated for daily vaginal checks, dosing, blood sampling and ultrasound analyses. In addition, the NPCC trains investigators in established protocols and disseminates information on emerging approaches. The NPCC represents an efficient use of animals and personnel, and provides assistance that is prohibitively expensive to establish in individual investigator's laboratories.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD055744-05
Application #
8232179
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
2012-08-31
Budget Start
2011-03-01
Budget End
2013-02-28
Support Year
5
Fiscal Year
2011
Total Cost
$320,727
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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Hanna, Carol B; Yao, Shan; Ramsey, Cathy M et al. (2015) Phosphodiesterase 3 (PDE3) inhibition with cilostazol does not block in vivo oocyte maturation in rhesus macaques (Macaca mulatta). Contraception 91:418-22
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2015) Characterization of tubal occlusion after transcervical polidocanol foam (PF) infusion in baboons. Contraception 92:96-102
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Edelman, Alison B; Jensen, Jeffrey T; Doom, Carmen et al. (2013) Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women. Contraception 87:352-7
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Stouffer, Richard L; Bishop, Cecily V; Bogan, Randy L et al. (2013) Endocrine and local control of the primate corpus luteum. Reprod Biol 13:259-71
Micks, Elizabeth; Shekell, Taylor; Stanley, Jessica et al. (2012) Medical termination of pregnancy in cynomolgus macaques. J Med Primatol 41:394-402
Keator, Christopher S; Mah, Kuni; Slayden, Ov D (2012) Alterations in progesterone receptor membrane component 2 (PGRMC2) in the endometrium of macaques afflicted with advanced endometriosis. Mol Hum Reprod 18:308-19
Hanna, Carol B; Yao, Shan; Wu, Xuemei et al. (2012) Identification of phosphodiesterase 9A as a cyclic guanosine monophosphate-specific phosphodiesterase in germinal vesicle oocytes: a proposed role in the resumption of meiosis. Fertil Steril 98:487-95.e1

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