The Administrative (Admin) Core, co-directed by Richard L. Stouffer, Ph.D., and Jeffrey T. Jensen, M.D., will promote the timely, efficient performance of the CDRC-sponsored projects outlined in this renewal application. This will be accomplished, in part, by coordinating the exchange of information, ideas and expertise between: (1) project investigators and core supervisors within the ONPRC-OHSU Center, (2) ONPRC-OHSU investigators and collaborators from other CDRC-Sponsored programs, as well as NICHD program officers and scientists, and (3) ONPRC-OHSU investigators and collaborators from pharmaceutical companies (e.g., Bayer AG, Beriin, Germany) and clinical programs (e.g.. Family Planning, Ob-Gyn, OHSU). In addition, the Admin Core will assist in the recruitment and development of beginning scientists and trainees electing to pursue careers in contraceptive research. The core will also liaison with the Outreach program at ONPRC, OHSU West Campus, to promote awareness of the need and advances in contraceptive research to school-age-children and the general public. CDRC research projects, including scientific advances and experimental challenges, will be evaluated within the weekly seminar programs of the Division of Reproductive &Developmental Sciences, ONPRC and Ob-Gyn Grand Rounds, OHSU, as well as quarterly meetings of the center's personnel, in discussions with the External Advisory Board, and review of progress reports prepared for the noncompetitive renewal to NICHD and the annual U54/U01 Contraception Research Meeting. Through the Admin Core's efforts and oversight, scientific and technological advances in reproductive biology, particularly pertaining to the control of periovulatory events in primates, can be applied within the nonhuman primate (NHP) core and translated by clinical investigators into Phase 1 trials. This program, and collaborations with other contraceptive programs, will promote the development of novel contraceptive modalities aimed at selectively disrupting gamete maturation, release or transport in primates, and ultimately in humans.

Public Health Relevance

The Administrative (Admin) Core, co-directed by Richard L. Stouffer, Ph.D., and Jeffrey T. Jensen, M.D., will promote the timely, efficient performance of the CDRC-sponsored projects outlined in this renewal application. This program, and collaborations with other contraceptive programs, will promote the development of novel contraceptive modalities aimed at selectively disrupting gamete maturation, release or transport in primates, and ultimately in humans.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD055744-08
Application #
8699802
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97239
Jakkaraj, Sudhakar; Young Jr, Victor G; Georg, Gunda I (2018) Syntheses of PDE3A inhibitor ORG9935 and determination of the absolute stereochemistries of its enantiomers by X-ray crystallography. Tetrahedron 74:2769-2774
Slayden, Ov Daniel; Friason, Francis Kathryn E; Bond, Kise Rosen et al. (2018) Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix. J Med Primatol 47:362-370
Stouffer, Richard L; Woodruff, Teresa K (2017) Nonhuman Primates: A Vital Model for Basic and Applied Research on Female Reproduction, Prenatal Development, and Women's Health. ILAR J 58:281-294
Zhu, Jin-Yi; Cuellar, Rebecca A; Berndt, Norbert et al. (2017) Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem 60:7863-7875
Slayden, Ov D; Lee, Dong Ock; Yao, Shan et al. (2016) Polidocanol induced tubal occlusion in nonhuman primates: immunohistochemical detection of collagen I-V. Contraception 94:521-526
Hanna, Carol B; Yao, Shan; Ramsey, Cathy M et al. (2015) Phosphodiesterase 3 (PDE3) inhibition with cilostazol does not block in vivo oocyte maturation in rhesus macaques (Macaca mulatta). Contraception 91:418-22
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2015) Characterization of tubal occlusion after transcervical polidocanol foam (PF) infusion in baboons. Contraception 92:96-102
Peluffo, M C; Stanley, J; Braeuer, N et al. (2014) A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques. Hum Reprod 29:1400-12
Peluffo, Marina C; Hennebold, Jon D; Stouffer, Richard L et al. (2013) Oocyte maturation and in vitro hormone production in small antral follicles (SAFs) isolated from rhesus monkeys. J Assist Reprod Genet 30:353-9
Edelman, Alison B; Jensen, Jeffrey T; Doom, Carmen et al. (2013) Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women. Contraception 87:352-7

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