The Administrative (Admin) Core, co-directed by Richard L. Stouffer, Ph.D., and Jeffrey T. Jensen, M.D., will promote the timely, efficient performance of the CDRC-sponsored projects outlined in this renewal application. This will be accomplished, in part, by coordinating the exchange of information, ideas and expertise between: (1) project investigators and core supervisors within the ONPRC-OHSU Center, (2) ONPRC-OHSU investigators and collaborators from other CDRC-Sponsored programs, as well as NICHD program officers and scientists, and (3) ONPRC-OHSU investigators and collaborators from pharmaceutical companies (e.g., Bayer AG, Beriin, Germany) and clinical programs (e.g.. Family Planning, Ob-Gyn, OHSU). In addition, the Admin Core will assist in the recruitment and development of beginning scientists and trainees electing to pursue careers in contraceptive research. The core will also liaison with the Outreach program at ONPRC, OHSU West Campus, to promote awareness of the need and advances in contraceptive research to school-age-children and the general public. CDRC research projects, including scientific advances and experimental challenges, will be evaluated within the weekly seminar programs of the Division of Reproductive &Developmental Sciences, ONPRC and Ob-Gyn Grand Rounds, OHSU, as well as quarterly meetings of the center's personnel, in discussions with the External Advisory Board, and review of progress reports prepared for the noncompetitive renewal to NICHD and the annual U54/U01 Contraception Research Meeting. Through the Admin Core's efforts and oversight, scientific and technological advances in reproductive biology, particularly pertaining to the control of periovulatory events in primates, can be applied within the nonhuman primate (NHP) core and translated by clinical investigators into Phase 1 trials. This program, and collaborations with other contraceptive programs, will promote the development of novel contraceptive modalities aimed at selectively disrupting gamete maturation, release or transport in primates, and ultimately in humans.

Public Health Relevance

The Administrative (Admin) Core, co-directed by Richard L. Stouffer, Ph.D., and Jeffrey T. Jensen, M.D., will promote the timely, efficient performance of the CDRC-sponsored projects outlined in this renewal application. This program, and collaborations with other contraceptive programs, will promote the development of novel contraceptive modalities aimed at selectively disrupting gamete maturation, release or transport in primates, and ultimately in humans.

Agency
National Institute of Health (NIH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD055744-08
Application #
8699802
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97239
Peluffo, M C; Stanley, J; Braeuer, N et al. (2014) A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques. Hum Reprod 29:1400-12
Peluffo, Marina C; Hennebold, Jon D; Stouffer, Richard L et al. (2013) Oocyte maturation and in vitro hormone production in small antral follicles (SAFs) isolated from rhesus monkeys. J Assist Reprod Genet 30:353-9
Stouffer, Richard L; Bishop, Cecily V; Bogan, Randy L et al. (2013) Endocrine and local control of the primate corpus luteum. Reprod Biol 13:259-71
Edelman, Alison B; Jensen, Jeffrey T; Doom, Carmen et al. (2013) Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women. Contraception 87:352-7
Keator, Christopher S; Mah, Kuni; Slayden, Ov D (2012) Alterations in progesterone receptor membrane component 2 (PGRMC2) in the endometrium of macaques afflicted with advanced endometriosis. Mol Hum Reprod 18:308-19
Bogan, Randy L; Debarber, Andrea E; Hennebold, Jon D (2012) Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Biol Reprod 86:89
Keator, Christopher S; Mah, Kuni; Ohm, Lindsay et al. (2011) Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium. Hum Reprod 26:1715-28
Xu, Fuhua; Stouffer, Richard L; Muller, Jorg et al. (2011) Dynamics of the transcriptome in the primate ovulatory follicle. Mol Hum Reprod 17:152-65
Peluffo, Marina C; Murphy, Melinda J; Baughman, Serena Talcott et al. (2011) Systematic analysis of protease gene expression in the rhesus macaque ovulatory follicle: metalloproteinase involvement in follicle rupture. Endocrinology 152:3963-74
Peluffo, Marina C; Barrett, Susan L; Stouffer, Richard L et al. (2010) Cumulus-oocyte complexes from small antral follicles during the early follicular phase of menstrual cycles in rhesus monkeys yield oocytes that reinitiate meiosis and fertilize in vitro. Biol Reprod 83:525-32

Showing the most recent 10 out of 17 publications