The proposed Specialized Cooperative Center Program in Reproductive and Infertility Research (SCCPIR) is focused upon female reproductive biology with Dr. Jeffrey W. Pollard as Principal Investigator. It has evolved out of an institutional supported """"""""Center for the Study of Reproductive Biology and Women's Health"""""""" founded in 2003 at the Albert Einstein College of Medicine with Dr. Pollard as Director. This Center drew together disparate strands of research in the female reproduction at the institution to form a distinct group of interactive individuals who have a translational focus. Investigators with this Center have worked for the last four years to develop this submission and in doing so have met regularly to undertake collaborative projects and used institutional funds to support clinical fellowship training relevant to the study of female reproduction. In doing so the PI's of the proposed projects have all published with one another and they have identified several fellows to be brought onto faculty to perform clinical/basic science research. The SCCPIR has four Projects (Projects 1 and 2 being clinical) and an administrative core as follows: Project 1. Dr. Jeffrey Pollard (PI) - Estrogen and Progesterone Regulation of Human Endometrial Cell Proliferation. Project 2. Dr. Nanette Santoro (PI) - Reproductive hormonal alterations in obesity. Project 3. Dr. Anne Etgen (PI) - IGF-I and Neuroendocrine Regulation of Female Reproductive Function. Project 4. Dr. Streamson Chua (PI) - Antagonistic actions of melanocortins and leptin on reproductive competence. A senior investigator leads all of these projects. There is integration amongst the projects through studies on the roles of obesity and nutrition in reproductive biology as well as the relationship between the insulin-like growth factor-1 axis and estrogen action. The PI, Dr. Jeffrey W. Pollard, is an internationally known researcher in reproductive biology having been, amongst other things, Chair of the Reproductive Tract Gordon Conference. He holds several senior administrative appointments in the College of Medicine and is well able to administer the proposed SCCPIR internally and to enable effective interactions with other SCCPIRs.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-L (54))
Program Officer
De Paolo, Louis V
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Albert Einstein College of Medicine
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Al-Safi, Zain A; Polotsky, Alex; Chosich, Justin et al. (2018) Evidence for disruption of normal circadian cortisol rhythm in women with obesity. Gynecol Endocrinol 34:336-340
Chosich, Justin; Bradford, Andrew P; Allshouse, Amanda A et al. (2017) Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity (Silver Spring) 25:553-560
Kuokkanen, Satu; Zhu, Liyin; Pollard, Jeffrey W (2017) Xenografted tissue models for the study of human endometrial biology. Differentiation 98:62-69
Al-Safi, Zain A; Liu, Huayu; Carlson, Nichole E et al. (2016) Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab 101:324-33
Kuokkanen, Satu; Polotsky, Alex J; Chosich, Justin et al. (2016) Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med 62:227-42
Merhi, Zaher; Polotsky, Alex J; Bradford, Andrew P et al. (2015) Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci 22:1220-8
Wang, Yuxiang; Zhu, Liyin; Kuokkanen, Satu et al. (2015) Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17? is mediated by a PKC-ERK1/2-mTOR signaling pathway. Proc Natl Acad Sci U S A 112:E1382-91
Wooding, Kerry M; Hankin, Joseph A; Johnson, Chris A et al. (2015) Measurement of estradiol, estrone, and testosterone in postmenopausal human serum by isotope dilution liquid chromatography tandem mass spectrometry without derivatization. Steroids 96:89-94
Kauffman, Alexander S; Sun, Yan; Kim, Joshua et al. (2014) Vasoactive intestinal peptide modulation of the steroid-induced LH surge involves kisspeptin signaling in young but not in middle-aged female rats. Endocrinology 155:2222-32
Ross, Lauren A; Polotsky, Alex J; Kucherov, Alexander et al. (2014) Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring) 22:1464-9

Showing the most recent 10 out of 41 publications