We propose to establish a Center of Excellence on childhood obesity research and training, based on a transdisciplinary systems science framework and methodologies. We propose to use systems modeling approaches with integrated application of spatial analysis. Modeling will be guided by behavioral models and basic science regarding food intake and body weight regulation to study the complex determinants of childhood obesity and the impacts of environmental and policy interventions. We will undertake epidemiological research to study the cascading influences of macrosocial environmental factors on individual-level behaviors and biology using existing and new data from large cohorts of children and their families in the U.S. and in China. In proposed projects we synthesize epidemiological methods and designs with basic sciences to explore how social, environmental and individual factors relate synergistically to energy balance related behaviors to differential epigenetic programming. We will also evaluate a novel multilevel food access intervention that can become a model of effective and sustainable community-based interventions and policy changes, focusing on an urban low-income population at high risk of obesity. By combining features of previous effective intervention approaches, within a broader systems framework, we hope to make desirable, food choices more accessible, sustainable, and cost effective. In addition, we will encourage and support developmental research to develop and evaluate environmental and policy interventions in the proposed Pilot Study Core. We will establish a computational workshop for systems modeling and GIS-based investigation (Research Resource Core and Training Core) that will provide an infrastructure to advance the Center's training and research mission. We will train a new cohort of investigators at different career stages in emerging system-science theories and methods. Over 40 well established investigators from leading US and international institutions bring transdisciplinary expertise to bear in highly relevant areas. The Center will build upon a solid research and training base with ongoing NIH funded projects directly related to childhood obesity and systems analysis.

Public Health Relevance

We propose to establish a Center of Excellence on childhood obesity research and training based on a transdisciplinary systems science framework, systems-based methodologies, and spatial analysis to study the complex etiology of childhood obesity and the impacts of environmental and policy interventions. We will establish an innovative infrastructure for related research and training, and support new pilot projects.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD070725-03
Application #
8481562
Study Section
Special Emphasis Panel (ZHD1-DSR-A (01))
Program Officer
Grave, Gilman D
Project Start
2011-09-22
Project End
2016-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
3
Fiscal Year
2014
Total Cost
$2,868,245
Indirect Cost
$919,852
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Powell-Wiley, Tiffany M; Wong, Michelle S; Adu-Brimpong, Joel et al. (2017) Simulating the Impact of Crime on African American Women's Physical Activity and Obesity. Obesity (Silver Spring) 25:2149-2155
Lee, Bruce Y; Ferguson, Marie C; Hertenstein, Daniel L et al. (2017) Simulating the Impact of Sugar-Sweetened Beverage Warning Labels in Three Cities. Am J Prev Med :
Lee, Bruce Y; Mueller, Leslie E; Tilchin, Carla G (2017) A systems approach to vaccine decision making. Vaccine 35 Suppl 1:A36-A42
Beheshti, Rahmatollah; Jalalpour, Mehdi; Glass, Thomas A (2017) Comparing methods of targeting obesity interventions in populations: An agent-based simulation. SSM Popul Health 3:211-218
Mui, Yeeli; Jones-Smith, Jessica C; Thornton, Rachel L J et al. (2017) Relationships between Vacant Homes and Food Swamps: A Longitudinal Study of an Urban Food Environment. Int J Environ Res Public Health 14:
Zhang, Xin-Yu; Gao, Ying; Li, Chang-Ping et al. (2017) Observed and projected trends in paediatric health resources and services in China between 2003 and 2030: a time-series study. BMJ Open 7:e015000
Bartsch, S M; McKinnell, J A; Mueller, L E et al. (2017) Potential economic burden of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Clin Microbiol Infect 23:48.e9-48.e16
Hopkins, Laura C; Sattler, Melissa; Steeves, Elizabeth Anderson et al. (2017) Breakfast Consumption Frequency and Its Relationships to Overall Diet Quality, Using Healthy Eating Index 2010, and Body Mass Index among Adolescents in a Low-Income Urban Setting. Ecol Food Nutr 56:297-311

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