The Administrative Core will be responsible for oversight of all administrative aspects of the NYPD-PRC. The administrative core team will facilitate communication amongst all the NYPD-PRC sites, scheduling meetings and seminars and disseminating research information about each project. The Administrative Core team will also negotiate subcontracts and ensure that all sites receive appropriate payment and produce accounting at the end of each budget period. They will keep statistics about site involvement in studies, enrollment across participating sites, AE/SAE reporting to sponsor or FDA (depending on sponsored or investigator-initiated research), internal monitoring and study close-out. 2. Communication between a member of the Administrative Core team and the sites and Cores will occur once every two weeks or more often if necessary. The Administrative Core, with the aid of advice from the core directors, will create and manage the mechanism for soliciting new investigator projects to receive funding from the NYPD-PRC. New projects will be sought from each institution in the consortium. Each project will be reviewed by the Administrative Core and other core directors. These reviewers will critique each project based on scientific merit, feasibility, and necessity for NYPD-PRC cores. The project judged most in keeping with the goals of the consortium will be granted funding for one year, with additional years of funding contingent upon need and scientific progress. The goals of the administrative core are: 1) To organize training and outreach across the participating sites and the BQNN. The network presents a rich environment for young investigators to be exposed to and develop additional research skills and to assist them in progressing to more senior status;2) To provide Cores and investigators reminders of potential funding opportunities through dissemination of FOAs and RFAs electronically to all sites;and 3) To provide regular updates (once every 3 months) or ad hoc on the progress and problems in the consortium. The Outreach Program is imbedded in the Administrative Core with Aranda and Jusko as Co-directors. A key role of the NYPD-PRC is the mentoring of younger investigators, from students to junior faculty. The pool of senior mentors in translational research is deep across collaborating institutions affording unique advantages to traditional brick-and-mortar institutions. By design, the core modules will afford these younger members of the community access to expertise, technology and advice that is not possible otherwise.

National Institute of Health (NIH)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Suny Downstate Medical Center
United States
Zip Code
Nouri-Nigjeh, Eslam; Sukumaran, Siddharth; Tu, Chengjian et al. (2014) Highly multiplexed and reproducible ion-current-based strategy for large-scale quantitative proteomics and the application to protein expression dynamics induced by methylprednisolone in 60 rats. Anal Chem 86:8149-57
Tu, Chengjian; Mammen, Manoj Jacob; Li, Jun et al. (2014) Large-scale, ion-current-based proteomics investigation of bronchoalveolar lavage fluid in chronic obstructive pulmonary disease patients. J Proteome Res 13:627-39
An, Bo; Zhang, Ming; Qu, Jun (2014) Toward sensitive and accurate analysis of antibody biotherapeutics by liquid chromatography coupled with mass spectrometry. Drug Metab Dispos 42:1858-66
Tu, Chengjian; Li, Jun; Sheng, Quanhu et al. (2014) Systematic assessment of survey scan and MS2-based abundance strategies for label-free quantitative proteomics using high-resolution MS data. J Proteome Res 13:2069-79
Nouri-Nigjeh, Eslam; Zhang, Ming; Ji, Tao et al. (2014) Effects of calibration approaches on the accuracy for LC-MS targeted quantification of therapeutic protein. Anal Chem 86:3575-84
Qu, Jun; Young, Rebeccah; Page, Brian J et al. (2014) Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models. J Proteome Res 13:2571-84
Gui, Shanying; Gathiaka, Symon; Li, Jun et al. (2014) A remodeled protein arginine methyltransferase 1 (PRMT1) generates symmetric dimethylarginine. J Biol Chem 289:9320-7
Shen, Xiaomeng; Young, Rebeccah; Canty, John M et al. (2014) Quantitative proteomics in cardiovascular research: global and targeted strategies. Proteomics Clin Appl 8:488-505
Chen, Ting; Mager, Donald E; Kagan, Leonid (2013) Interspecies modeling and prediction of human exenatide pharmacokinetics. Pharm Res 30:751-60
Beharry, Kay D; Cai, Charles L; Sharma, Poonam et al. (2013) Hydrogen peroxide accumulation in the choroid during intermittent hypoxia increases risk of severe oxygen-induced retinopathy in neonatal rats. Invest Ophthalmol Vis Sci 54:7644-57

Showing the most recent 10 out of 13 publications