The Indiana Center for Pediatric Pharmacology (ICPP) is a highly collaborative group of multidisciplinary investigators that have worked together productively for almost a decade. Its research has focused on the effects of germ line genomics on the efficacy and safety of medications for children. The center represents a highly productive model of interdisciplinary collaboration, that has significantly impacted this field of investigation, and generated a large amount of preliminary data that support this application. The Administrative Core involves five key leaders: Drs Flockhart. Renbarger. Haneline. Robertson and Bies. This leadership group provides close, strategic oversight of the Core, which is managed by Drs. Renbarger and Flockhart, the ICPP PIs.
The Aims of the core are: 1) To organize communication within and between the ICPP projects and cores, including: serving as a communication structure for fiscal management, maintaining all central documents, organizing collaborative manuscript and proposal preparation, and maintaining of regular meeting and teleconference schedule;and 2) To organize the effective flow of curated data between the three projects, the Biostatistics and Modeling Core, and the genotyping and analytical labs. This Core is central to the management of the large amounts of data generated, and is responsible for the auditing and quality control of that data: it is the coordinating engine at the center of the IPCC's research. All clinical, genomic, proteomic, and in vitro data generated from projects are sent to the core, where they are stored in the caArray secure data management system before being sent to the Biostatistics and Modeling Core for analysis as data are generated from specific projects and pilots. The Administrative Core serves all projects and is the key organizer of communication between the projects and the Biostatistics and Modeling core. The Core is also responsible for the coordination and organization of the wide range of regular interactions of these investigators. These include national and international scientific meetings, weekly phone/web conferences, monthly executive committee meetings and yearly retreats with our scientific advisory committee.

Public Health Relevance

The Administrative Core proposed in this application is important to organize communication between this diverse, multidisciplinary group of investigators and to organize effective flow of data between the projects and cores. These roles are critical to the efficiency and success of the ICPP.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-A)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
United States
Zip Code
Skiles, Jodi L; Chiang, ChienWei; Li, Claire H et al. (2018) CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer. Pediatr Blood Cancer 65:
Stark, Julie; Renbarger, Jamie; Slaven, James et al. (2017) Glutathione-S-transferase P1 may predispose children to a decline in pulmonary function after stem cell transplant. Pediatr Pulmonol 52:916-921
Sierra Potchanant, Elizabeth A; Cerabona, Donna; Sater, Zahi Abdul et al. (2017) INPP5E Preserves Genomic Stability through Regulation of Mitosis. Mol Cell Biol 37:
Taylor, Julia F; Ott, Mary A (2016) Fertility Preservation after a Cancer Diagnosis: A Systematic Review of Adolescents', Parents', and Providers' Perspectives, Experiences, and Preferences. J Pediatr Adolesc Gynecol 29:585-598
Akil, Ayman; Zhang, Qing; Mumaw, Christen L et al. (2015) Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant 21:1739-45
McGuire, Jennifer L; Barrett, Jeffrey S; Vezina, Heather E et al. (2014) Adjuvant therapies for HIV-associated neurocognitive disorders. Ann Clin Transl Neurol 1:938-52
Nalepa, Grzegorz; Barnholtz-Sloan, Jill; Enzor, Rikki et al. (2013) The tumor suppressor CDKN3 controls mitosis. J Cell Biol 201:997-1012
Hennessy, S; Flockhart, D A (2012) The need for translational research on drug-drug interactions. Clin Pharmacol Ther 91:771-3