The Pilot Project studies will support the overall program entitled "Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy", submitted as an application responsive to RFA-HD-10-026: Specialized Center in Research in Pediatric Developmental Pharmacology (RPDP) Program (U54). The overall theme of the proposed program at the UC San Diego is to bring together non-clinical and clinical experts in the fields of developmental physiology, pharmacology, and infectious diseases to advance the field of pediatric developmental pharmacology. To promote the development of innovated research ideas and foster new collaborations, the UC San Diego RPDP Center includes a Pilot Project program. This program supports limited Pilot Projects for 1 or 2 years in duration to generate focused explorations related to existing RPDP Center Projects or to generate preliminary information for new Project applications. These Pilot Projects may originate from within UC San Diego or from other NICHD supported RPDP Centers. Administrative Core will organize the solicitation and selection process and the Scientific Advisory Committee members will assist the PIs and Core Directors with selection. The Pilot Projects that address general developmental pharmacologic issues not specific to antibacterial therapeutics may be considered but must involve either the Pharmacometric Core, the Quantitative Pharmacology Assay Core or both. Projects that promote interactions with other RPDP Centers, support junior investigators and have the potential to provide the scientific basis for larger clinical trials will be encouraged. Two Pilot Projects were selected from an initial pool of applicants for UC San Diego RPDP Center Years 1-2. They are entitled "Plasma and intracellular cathelicidin responses to infection in infants and young children" and "Developmental changes in aminopenicillin renal excretion in infants and young children" and are linked to Projects II and III, respectively. Both of these projects utilize the Pharmacometric and Quantitative Pharmacology Assay Cores and provide opportunities for trainee involvement, as well. In program Years 2-4, solicitations will be made for the Year 3-5 Pilot Projects.

Public Health Relevance

Pilot exploratory studies provide an efficient, cost-effective manner to think-outside-of-the-box, test novel hypotheses and encourage collaborations with basic science and pediatric investigators new to pediatric pharmacology. The first two Pilot Projects will provide new information on human development of Oat transporters and provide the first normative data on systemic cathelicidin dynamic responses in pediatrics.

National Institute of Health (NIH)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZHD1)
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University of California San Diego
La Jolla
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Sampson, Mario R; Frymoyer, Adam; Rattray, Benjamin et al. (2014) Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia. Ther Drug Monit 36:584-9
Tremoulet, Adriana; Le, Jennifer; Poindexter, Brenda et al. (2014) Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother 58:3013-20
Sinko, William; Wang, Yang; Zhu, Wei et al. (2014) Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads. J Med Chem 57:5693-701
Le, Jennifer; Ngu, Becky; Bradley, John S et al. (2014) Vancomycin monitoring in children using bayesian estimation. Ther Drug Monit 36:510-8
Gonzalez, David J; Vuong, Lisa; Gonzalez, Isaiah S et al. (2014) Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Mol Cell Proteomics 13:1262-72
Sakoulas, George; Rose, Warren; Nonejuie, Poochit et al. (2014) Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother 58:1494-500
Autmizguine, Julie; Moran, Cassie; Gonzalez, Daniel et al. (2014) Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections. Pediatr Infect Dis J 33:e270-2
Sakoulas, George; Okumura, Cheryl Y; Thienphrapa, Wdee et al. (2014) Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl) 92:139-49
Bayer, Arnold S; Mishra, Nagendra N; Sakoulas, George et al. (2014) Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides. Antimicrob Agents Chemother 58:7462-7
Liu, Yan; Haste, Nina M; Thienphrapa, Wdee et al. (2014) Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III). Mar Drugs 12:2458-70

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