The goals of the Administrative (Admin) Core are: (1) to coordinate the timely generation and exchange of research ideas and information among OHSU SCCPIR project investigators, including the seamless interaction with consortium activities at the University of Pittsburgh (Project 1;Dr. J. Cameron), and the University of California, Los Angeles (Project IV, Drs. D. Dumesic and G. Chazenbalk), (2) to facilitate the maintenance and efficient use of female rhesus monkeys within the Nonhuman Primate (NHP) Core, including the assignment and monitoring of the four experimental treatment groups as used by Projects l-lll, plus completion of the fertility trial, (3) to promote the training and career development of basic/clinical scientists electing to pursue research in reproduction and infertility research, (4) to support outreach activities that increase community and student awareness of the values of research and advances in reproductive health, and (5) to integrate the activities of the OHSU SCCPIR with those of other NICHD-funded U54 Centers and scientists through interactions with the NICHD Research Coordinator, the SCCPIR Steering Committee, and various focus groups. The Supervisor of the Admin Core, and P.I. of the OHSU SCCPIR Center, is Richard L. Stouffer, Ph.D., Senior Scientist and Head, Division of Reproductive &Developmental Sciences, Oregon National Primate Research Center and Professor, Department of Obstetrics &Gynecology, OHSU. Dr. Stouffer will be responsible for the day-to-day oversight of SCCPIR operations. To provide assistance to the P.I., in resolution of problems, review of progress, and research planning, three types of committees will operate: (1) an External Advisory Board comprised of five prominent scientists from outside OHSU will annually provide research review and visioning, including review of collaborative (cross-center) pilot projects, (2) an Internal Advisory Board of scientists within OHSU will provide advice on day-to-day operations, plus assist in selection of cross-SCCPIR trainees, and (3) Core Oversight Committees (for the NHP and Outreach Cores) will provide annual review of core activities and recommendations for improvement. The P.l./Admin Core Supervisor will interact regularly with ONPRC, OHSU and NICHD officials to promote SCCPIR programs locally, nationally and internationally.
; Infertility is a significant detractor to women's health. The Admin Core will promote translational research to examine the roles of two prevalent conditions, hyperandrogenemia and metabolic changes due to a high fat/sugar diet, on the female reproductive system (as well as adipose tissue) and fertility. Also the reversibility of treatment effects, and hence possible modalities for therapy, will be explored.
|Bishop, Cecily V; Xu, Fuhua; Xu, Jing et al. (2016) Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys. Fertil Steril 105:1023-34|
|Rodrigues, J K; Navarro, P A; Zelinski, M B et al. (2015) Direct actions of androgens on the survival, growth and secretion of steroids and anti-MÃ¼llerian hormone by individual macaque follicles during three-dimensional culture. Hum Reprod 30:664-74|
|Dumesic, Daniel A; Goodarzi, Mark O; Chazenbalk, Gregorio D et al. (2014) Intrauterine environment and polycystic ovary syndrome. Semin Reprod Med 32:159-65|
|Simerman, Ariel A; Perone, Marcelo J; Gimeno, MarÃa L et al. (2014) A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues. Expert Opin Biol Ther 14:917-29|
|McGee, W K; Bishop, C V; Pohl, C R et al. (2014) Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys. Am J Physiol Endocrinol Metab 306:E1292-304|
|Keller, Erica; Chazenbalk, Gregorio D; Aguilera, Paul et al. (2014) Impaired preadipocyte differentiation into adipocytes in subcutaneous abdominal adipose of PCOS-like female rhesus monkeys. Endocrinology 155:2696-703|
|Amin, Marli; Simerman, Ariel; Cho, Michele et al. (2014) 21-Hydroxylase-derived steroids in follicles of nonobese women undergoing ovarian stimulation for in vitro fertilization (IVF) positively correlate with lipid content of luteinized granulosa cells (LGCs) as a source of cholesterol for steroid synthesis. J Clin Endocrinol Metab 99:1299-306|
|Heneidi, Saleh; Simerman, Ariel A; Keller, Erica et al. (2013) Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue. PLoS One 8:e64752|
|Chazenbalk, Gregorio; Singh, Prapti; Irge, Dana et al. (2013) Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation. Steroids 78:920-6|
|Varlamov, Oleg; Chu, Michael P; McGee, Whitney K et al. (2013) Ovarian cycle-specific regulation of adipose tissue lipid storage by testosterone in female nonhuman primates. Endocrinology 154:4126-35|
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