The Administrative Core and its strong administrative team will provide a structure to facilitate the activities and meet the needs of the individual research Projects and Cores of the Center for Reproductive Health After Disease. The principle missions of the Core are: to reduce administrative barriers within and between Center Projects and Cores so researchers can focus on advancing reproductive science;foster team science by facilitating communication within the Center;engage the next generation of independent researchers;and evaluate Center progress in order to speed the pace and quality of research. The Core will reduce administrative barners by providing centralized accounting, budgeting, and administrative services to the Project and Core teams and to the overall Center. The Core will further ease the burden on the research teams by facilitating all grant renewals and providing regulatory support to ensure compliance for all projects and research personnel. The Core will also handle any human resources and immigration considerations. Utilizing established methodologies, the Core will foster team science to integrate the Center's research efforts and will support frequent and straightforward communication between the individual research Projects and Cores. The Core will organize in-person and virtual scientific meetings, which will increase collaboration and accelerate the pace and quality of translation research. The Core will also schedule and organize an annual meeting of Pis, to be coordinated with the established annual Oncofertility Conference, which attracts a national group of scientists, researchers, and clinicians to present advances in reproductive and endocrine science in the disease context. The Core will maintain a thorough and up-to-date website to disseminate research findings and resources to the larger community of researchers and clinicians in women's reproductive health, as well as host publications, video, and overviews of each of the Projects and Cores. In order to engage the next generation of independent researchers, a twice-yearly cross-center research training program will be organized by the Core to provide trainees with an opportunity to gain hands-on experience in cutting-edge techniques such as follicle isolation, manipulation, encapsulation in biomaterials, and culture for in vitro follicle growth. The Core will also evaluate Center progress by supporting Internal, External, and Community Advisory Committees and an Information Technology Strategic Development Committee, and by monitoring the progress of each Project and Core. The Core will manage requests for proposals for pilot projects and work with the Pilot Project Advisory and Assessment Committee to identify exemplary pilot proposals, recommend them to the SCCPIR pilot committee, and evaluate their progress. Through these means, the Core will facilitate and coordinate research efforts and support the dissemination of the Center's work to the reproductive health research community and the many medical disciplines that provide care for patients whose reproductive health is at risk from their disease or its treatment.

Public Health Relevance

, The Administrative Core of the Center for Reproductive Health After Disease will reduce administrative barriers to individual Projects and Cores so that their efforts are focused on achieving the research goals of the Center;foster communication between investigators at the Center, within the SCCPIR program, and in aligned communities;and train the next generation of researchers on translational research methods in reproductive science. In collaboration with Internal and External Advisory Committees, the Core will frequently assess the progress of the individual Projects and Cores and provide guidance to Principle Investigators to address research barriers and ensure a rapid pace of high-quality reproductive health research by the team.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HD076188-01
Application #
8510778
Study Section
Special Emphasis Panel (ZHD1-DSR-L (55))
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
1
Fiscal Year
2013
Total Cost
$322,798
Indirect Cost
$113,867
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Silva, G M; Rossetto, R; Chaves, R N et al. (2015) In vitro development of secondary follicles from pre-pubertal and adult goats cultured in two-dimensional or three-dimensional systems. Zygote 23:475-84
Tagler, David; Makanji, Yogeshwar; Tu, Tao et al. (2014) Promoting extracellular matrix remodeling via ascorbic acid enhances the survival of primary ovarian follicles encapsulated in alginate hydrogels. Biotechnol Bioeng 111:1417-29
Kong, B Y; Duncan, F E; Que, E L et al. (2014) Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition. Mol Hum Reprod 20:1077-89
Lawson, Angela K; Klock, Susan C; Pavone, Mary Ellen et al. (2014) Prospective study of depression and anxiety in female fertility preservation and infertility patients. Fertil Steril 102:1377-84
Smith, Rachel M; Shikanov, Ariella; Kniazeva, Ekaterina et al. (2014) Fibrin-mediated delivery of an ovarian follicle pool in a mouse model of infertility. Tissue Eng Part A 20:3021-30
Pavone, Mary Ellen; Hirshfeld-Cytron, Jennifer; Tingen, Candace et al. (2014) Human ovarian tissue cortex surrounding benign and malignant lesions. Reprod Sci 21:582-9
Shea, Lonnie D; Woodruff, Teresa K; Shikanov, Ariella (2014) Bioengineering the ovarian follicle microenvironment. Annu Rev Biomed Eng 16:29-52
Lyttle, B; Bernardi, L; Pavone, M E (2014) Ovarian cancer in endometriosis: clinical and molecular aspects. Minerva Ginecol 66:155-64
De Vos, Michel; Smitz, Johan; Woodruff, Teresa K (2014) Fertility preservation in women with cancer. Lancet 384:1302-10
Laronda, Monica M; Duncan, Francesca E; Hornick, Jessica E et al. (2014) Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. J Assist Reprod Genet 31:1013-28

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