This revised application for continued support of the Intellectual and Developmental Disabilities Research Center (IDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-14-012. The IDDRC will continue supporting a large, diverse, and multidisciplinary program of research focused on developmental disorders with an emphasis on translational research, serving as the nexus for research focused on developmental disabilities within one of the premiere educational, clinical, and biomedical research institutions in the world. The IDDRC will include six Cores. An Administrative Core (A) will provide leadership, management, and organizational support for the Center;coordinate educational program components (lectures and seminars);represent the Center in interactions with Institute and University administration;and serve as the interface wit colleagues at NICHD, other IDDRCs, and the broader community. A Clinical Translational Core (B) will support Center investigators in activities related to participant recruitment, IRB-related activities, biostatistics, and moving findings along the entire translational pathway. A Genetics Core (C) will provide centralized tissue culture and assistance with cytogenetics, specialized molecular genetics, microarray and sequencing studies, and bioinformatics. A Translational Neuroscience Core (D) will provide histology and preclinical imaging facilities, as well as a group of highly specialized assays that target metabolites and molecules of relevance to developmental disorders. A Neuroimaging Core (E) will provide Investigators with assistance in acquisition and quantitative analysis of data derived from functional, volumetric, diffusion tensor and spectroscopic MR imaging, as well as for studies employing TMS methods. Finally, a Behavior Science Core (F) will offer training of participants for cooperation with research protocols, selection of methods for neuropsychological/cognitive assessment, design of activation paradigms for fMRI, and specialized methods for assessment of motor functioning. Core support this coming year will be provided to 69 projects representing annual federal funding of over $34 million, plus a Research Component funded directly by the Center.
Over 13% of school-age children may have a developmental disability (DD), many facing substantial lifelong impairments. Causes can be unclear and factors contributing to risk of primary and secondary concerns are only partially understood. The proposed Center will contribute to expanded understanding of the causes of developmental disorders as well as improvements in treatment and prevention.
|Stephens, Jaclyn A; Denckla, Martha B; McCambridge, Teri et al. (2018) Preliminary use of the PANESS for detecting subtle motor signs in adolescents with sport-related concussion: a brief report. Am J Phys Med Rehabil :|
|Mikkelsen, Mark; Loo, Rachelle S; Puts, Nicolaas A J et al. (2018) Designing GABA-edited magnetic resonance spectroscopy studies: Considerations of scan duration, signal-to-noise ratio and sample size. J Neurosci Methods 303:86-94|
|Slomine, Beth S; Silverstein, Faye S; Christensen, James R et al. (2018) Neurobehavioural outcomes in children after In-Hospital cardiac arrest. Resuscitation 124:80-89|
|Rosch, Keri S; Crocetti, Deana; Hirabayashi, Kathryn et al. (2018) Reduced subcortical volumes among preschool-age girls and boys with ADHD. Psychiatry Res Neuroimaging 271:67-74|
|Kim, Sangjune; Yun, Seung Pil; Lee, Saebom et al. (2018) GBA1 deficiency negatively affects physiological ?-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A 115:798-803|
|Pilarowski, Genay O; Vernon, Hilary J; Applegate, Carolyn D et al. (2018) Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability. J Med Genet 55:561-566|
|Statton, Matthew A; Vazquez, Alejandro; Morton, Susanne M et al. (2018) Making Sense of Cerebellar Contributions to Perceptual and Motor Adaptation. Cerebellum 17:111-121|
|Jacobson, Lisa A; Geist, Megan; Mahone, E Mark (2018) Sluggish Cognitive Tempo, Processing Speed, and Internalizing Symptoms: the Moderating Effect of Age. J Abnorm Child Psychol 46:127-135|
|Newcomb, Eli T; Hagopian, Louis P (2018) Treatment of severe problem behaviour in children with autism spectrum disorder and intellectual disabilities. Int Rev Psychiatry 30:96-109|
|Wang, Shuyan; Shi, Xiaohai; Wei, Shuang et al. (2018) Krüppel-like factor 4 (KLF4) induces mitochondrial fusion and increases spare respiratory capacity of human glioblastoma cells. J Biol Chem 293:6544-6555|
Showing the most recent 10 out of 198 publications