Massively parallel sequencing (MPS) technologies generate billions of sequence reads that must be mapped to complex genomes and interpreted. These technologies provide an unprecedented opportunity to develop diagnostic tools and treatments for individuals with developmental disorders. However, scientists cannot make full use of these technologies without a significant investment in computational capacity and bioinformatics expertise. Individual scientists typically do not have the resources to justify full-time support of personnel with bioinformatics expertise. Similarly, IDD research often involves small samples, with intensive assessment in multiple domains such as behavior, genetics and neuroimaging, along with longitudinal analysis taking account of developmental phenomena. These complex studies invariably require complex biostatistics methods for data analysis and careful attention to study design to ensure optimal statistical power. By utilizing overlapping computational resources and personnel to process complex biomedical data, this core is able to offer cost-effective services in biostatistics and bioinformatics. The Bioinformatics and Biostatistics Core has the following specific objectives: 1. To provide broad biostatistics support to IDDRC Investigators studying behavior, genetics, arid basic and clinical neuroscience. The BBC offers IDDRC investigators access to biostatistics experts that can help analyze data from preclinical, imaging and other clinical neuroscience data (e.g., EEG), genetics, and behavioral studies. The BBC will provide biostatistics support for pilot studies, consultation on study design and analysis, integrated analysis of multidisciplinary data, and assistance with accessing and coordinating additional statistical resources from other UNC services. 2. To provide comprehensive bioinformatics support to IDDRC Investigators. The research questions posed by IDDRC projects increasingly rely on 'omics'(e.g., including genomic, proteomics, epigenomics) or other data sources, requiring substantial biostatistics and bioinformatics expertise. The BBC offers state-of-the- art bioinformatics services and computational resources that are critically important to a large and growing number of IDDRC investigators. 3. To provide informal and formal training in biostatistics and bioinformatics. The Core will regularly provide informal teaching and training through consultation around design and analysis. BBC staff also contributes to the rich educational and training environment through the provision of a variety of existing seminars, classes, and demonstrations for trainees and investigators within the IDDRC.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Oguz, Ipek; Cates, Josh; Datar, Manasi et al. (2016) Entropy-based particle correspondence for shape populations. Int J Comput Assist Radiol Surg 11:1221-32
Hong, Junpyo; Vicory, Jared; Schulz, Jörn et al. (2016) Non-Euclidean classification of medically imaged objects via s-reps. Med Image Anal 31:37-45
Winkle, Cortney C; Olsen, Reid H J; Kim, Hyojin et al. (2016) Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory. J Neurosci 36:4940-58
Lee, Joohwi; Kim, Sun Hyung; Styner, Martin (2016) Multi-Object Model-based Multi-Atlas Segmentation for Rodent Brains using Dense Discrete Correspondences. Proc SPIE Int Soc Opt Eng 9784:
Pearson, Brandon L; Simon, Jeremy M; McCoy, Eric S et al. (2016) Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nat Commun 7:11173
Graham, Alice M; Buss, Claudia; Rasmussen, Jerod M et al. (2016) Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age. Dev Cogn Neurosci 18:12-25
Mabb, Angela M; Simon, Jeremy M; King, Ian F et al. (2016) Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS One 11:e0156439
Prieto, Juan C; Yang, Jean Y; Budin, François et al. (2016) Autotract: Automatic cleaning and tracking of fibers. Proc SPIE Int Soc Opt Eng 9784:
Kirby, Anne V; Little, Lauren M; Schultz, Beth et al. (2016) Development and Pilot of the Caregiver Strategies Inventory. Am J Occup Ther 70:7004360010p1-6
Lee, Joohwi; Kim, Sun Hyung; Oguz, Ipek et al. (2016) Enhanced Cortical Thickness Measurements for Rodent Brains via Lagrangian-based RK4 Streamline Computation. Proc SPIE Int Soc Opt Eng 9784:

Showing the most recent 10 out of 89 publications