The University of Washington Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC), based at the Center on Human Development and Disability (CHDD), provides a comprehensive interdisciplinary program of research designed to prevent, diagnose, and treat individuals with intellectual and developmental disabilities (IDD). Research is carried out within the framework of the following 8 Collaborative Research Areas (CRAs): (1) Autism and Related Disorders;(2) Brain Malformation Disorders;(3) Central Nervous System Injury;(4) Developmental Toxicology;(5) Environmental Influences and Behavioral Development;(6) Epilepsy;(7) Hearing Disorders, and (8) Learning Disabilities. All CRAs are interdisciplinary, include scientists and clinicians, and are designed to promote translational research. In this application, to facilitate the work of investigators at our IDDRC, we are requesting support for an Administrative Core (Core A) designed to provide scientific and programmatic leadership and four scientific cores: (1) Genetics (Core B) - functional and human genomics components;(2) Brain Imaging (Core C) - in vivo imaging for human studies and animal models;(3) Animal Behavior (Core D) ~ behavioral testing for mouse and non-human primate models;and (4) Clinical Translational (Core E) - promotes and supports all phases of the translational research cycle. The Administrative Core also includes a Behavioral Evaluation Center for behavioral phenotyping for human studies and a test consultation and resource center. We are also proposing to conduct a research project focusing on Joubert syndrome utilizing comprehensive - Omic approaches that is well integrated with cores and other IDDRC activities. Extensive research training and dissemination activities are also integral components of our IDDRC.

Public Health Relevance

We are proposing to support the research projects of over 60 investigators focusing on high priority areas in the field of IDD conducted within an overarching framework of translational research. Combining the expertise of committed and well-established IDD investigators at the University of Washington with core and related University of Washington resources places our IDDRC in a position to make important advances in understanding the underlying causes of and providing effective treatments for individuals with IDD.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HD083091-01
Application #
8845293
Study Section
Special Emphasis Panel (ZHD1-DSR-H (ID))
Program Officer
Parisi, Melissa
Project Start
2014-09-23
Project End
2019-06-30
Budget Start
2014-09-23
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$1,300,000
Indirect Cost
$355,475
Name
University of Washington
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Shickman, Ryan; Famula, Jessica; Tassone, Flora et al. (2018) Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord 33:628-636
Wang, Hao; Zhang, Liang; Abel, Glen M et al. (2018) Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice. Toxicol Sci 161:87-102
Jones, E J H; Dawson, G; Webb, S J (2018) Sensory hypersensitivity predicts enhanced attention capture by faces in the early development of ASD. Dev Cogn Neurosci 29:11-20
Shum, Sara; Kirkwood, Jay S; Jing, Jing et al. (2018) Validated HPLC-MS/MS Method To Quantify Low Levels of Domoic Acid in Plasma and Urine after Subacute Exposure. ACS Omega 3:12079-12088
Swanson, Meghan R; Shen, Mark D; Wolff, Jason J et al. (2018) Naturalistic Language Recordings Reveal ""Hypervocal"" Infants at High Familial Risk for Autism. Child Dev 89:e60-e73
Fry, Andrew E; Fawcett, Katherine A; Zelnik, Nathanel et al. (2018) De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain :
Cao, Jessica K; Detloff, Peter J; Gardner, Richard G et al. (2018) Sex-dependent behavioral impairments in the HdhQ350/+ mouse line. Behav Brain Res 337:34-45
Damiano-Goodwin, Cara R; Woynaroski, Tiffany G; Simon, David M et al. (2018) Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder. Dev Cogn Neurosci 29:41-53
St John, Tanya; Dawson, Geraldine; Estes, Annette (2018) Brief Report: Executive Function as a Predictor of Academic Achievement in School-Aged Children with ASD. J Autism Dev Disord 48:276-283
Marrus, Natasha; Eggebrecht, Adam T; Todorov, Alexandre et al. (2018) Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers. Cereb Cortex 28:750-763

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