Waisman Center investigators study intellectual and developmental disabilities (IDD) through investigating the brain structure and function of individuals exhibiting these conditions or at risk for these conditions, or in animal models of these conditions. The Waisman Brain Imaging Core (BIC) provides all of the tools and services required for these types of investigations and includes facilities for magnetic resonance imaging (MRI), human positron emission tomography (PET), high-resolution PET for animal imaging, ancillary physiological recordings during imaging, and extensive software tools and training for image analysis. This facility occupies a key role in providing systems level neuroscience that lies at the interface between the behavioral and molecular levels of analysis. We propose the following specific aims for the next project period.
Aim 1 is to develop and translate hardware and software technologies for magnetic resonance imaging (MRI) neuroimaging studies of normal development, atypical development, and neurodegeneration in both humans and animal models. The objectives of this aim encompass all of the major modalities of MRI and include structural MRI, diffusion weighted imaging to examine white matter connectivity, and functional MRI. We also provide access to a highly realistic MRI simulator to enable participants to acclimate to the procedures and rehearse the behavioral protocols that are used in scanning.
Aim 2 is to develop and translate radiotracers and methodologies for using positron emission tomography (PET) neuroimaging to study normal development, atypical development and neurodegeneration in humans. The objectives of this aim include radio- pharmaceutical development to translate the use of novel radiotracers for the study of molecules relevant to understanding IDD. The BIC provides access to expertise in radiotracer development and PET physics expertise to characterize the kinetics and quantification of novel PET neuroligands. The BIC also performs regular maintenance and quality control for the Siemens PET scanner.
Aim 3 is to provide high quality macaque and rodent PET neuroimaging services. The objectives of this aim include the maintenance of two microPET scanners and the development of protocols with PIs to use high resolution microPET imaging to characterize the neurochemistry of IDD in non-human primates and rodents.
Aim 4 is to provide training and technical support for investigators and their staffs in the use of all of the imaging modalities in the BIC. The objectives of this aim include the conduct of courses and training workshops, regular technical updates at BIC monthly meetings and lab meetings of the participating PIs, specialized consultation with the staff and students of PIs, development of specialized scanning sequences and data acquisition protocols for novel applications and consultation, and support in statistical analysis of imaging data.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD090256-04
Application #
9748874
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Darling-White, Meghan; Sakash, Ashley; Hustad, Katherine C (2018) Characteristics of Speech Rate in Children With Cerebral Palsy: A Longitudinal Study. J Speech Lang Hear Res 61:2502-2515
Gulinello, Maria; Mitchell, Heather A; Chang, Qiang et al. (2018) Rigor and reproducibility in rodent behavioral research. Neurobiol Learn Mem :
Patzlaff, Natalie E; Shen, Minjie; Zhao, Xinyu (2018) Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins. Brain Plast 3:205-223
Farrell, Emily; Armstrong, Annie E; Grimes, Adrian C et al. (2018) Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling. Front Physiol 9:1442
Rosengren, Karl S; Jiang, Matthew J; Kalish, Charles W et al. (2018) COMMENTARY: WHAT HEALS AND WHY? CHILDREN'S UNDERSTANDING OF MEDICAL TREATMENTS. Monogr Soc Res Child Dev 83:175-183
Story, Brad H; Vorperian, Houri K; Bunton, Kate et al. (2018) An age-dependent vocal tract model for males and females based on anatomic measurements. J Acoust Soc Am 143:3079
Barton-Hulsey, Andrea; Sevcik, Rose A; Romski, MaryAnn (2018) The Relationship Between Speech, Language, and Phonological Awareness in Preschool-Age Children With Developmental Disabilities. Am J Speech Lang Pathol 27:616-632
Ma, Ki H; Duong, Phu; Moran, John J et al. (2018) Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury. Glia 66:2487-2502
Li, Yue; Shen, Minjie; Stockton, Michael E et al. (2018) Hippocampal deficits in neurodevelopmental disorders. Neurobiol Learn Mem :
Muhammad, A K M G; Kim, Kevin; Epifantseva, Irina et al. (2018) Cell transplantation strategies for acquired and inherited disorders of peripheral myelin. Ann Clin Transl Neurol 5:186-200

Showing the most recent 10 out of 111 publications