CORE C. ADMINISTRATION AND MANAGEMENT A.
Specific Aims The goals of this core are to facilitate the scientific mission of the center in a way that is maximally responsive to the needs of our research and technical personnel.
Its specific aims are: 1. Provide administrative coordination of the overall research effort. 2. Facilitate interactions with MLPCN staff and investigators. 3. Manage budget and personnel issues related to the KU CMLD center.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HG005031-06
Application #
8528674
Study Section
Special Emphasis Panel (ZRG1-IFCN-K)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
6
Fiscal Year
2013
Total Cost
$166,844
Indirect Cost
$51,703
Name
University of Kansas Lawrence
Department
Type
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Schroeder, Chad E; Yao, Tuanli; Sotsky, Julie et al. (2014) Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. J Med Chem 57:8608-21
Chou, Tsui-Fen; Bulfer, Stacie L; Weihl, Conrad C et al. (2014) Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol 426:2886-99
Goller, Carlos C; Arshad, Mehreen; Noah, James W et al. (2014) Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis. PLoS One 9:e96054
Flaherty, Daniel P; Simpson, Denise S; Miller, Melissa et al. (2014) Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett 24:3968-73
Mukherjee, Sourav; Weiner, Warren S; Schroeder, Chad E et al. (2014) Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication. ACS Chem Biol 9:2393-403
Chung, Dong-Hoon; Moore, Blake P; Matharu, Daljit S et al. (2013) A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus. Virol J 10:19
Sweeney, Noreena L; Shadrick, William R; Mukherjee, Sourav et al. (2013) Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. J Biol Chem 288:19949-57
Chou, Tsui-Fen; Li, Kelin; Frankowski, Kevin J et al. (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8:297-312
Coombs, Thomas C; Tanega, Cordelle; Shen, Min et al. (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett 23:3654-61
Zhang, Jintao; Huan, Jun (2013) Predicting drug-induced QT prolongation effects using multi-view learning. IEEE Trans Nanobioscience 12:206-13

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