CORE C. ADMINISTRATION AND MANAGEMENT A.
Specific Aims The goals of this core are to facilitate the scientific mission of the center in a way that is maximally responsive to the needs of our research and technical personnel.
Its specific aims are: 1. Provide administrative coordination of the overall research effort. 2. Facilitate interactions with MLPCN staff and investigators. 3. Manage budget and personnel issues related to the KU CMLD center.
|Schroeder, Chad E; Yao, Tuanli; Sotsky, Julie et al. (2014) Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. J Med Chem 57:8608-21|
|Chou, Tsui-Fen; Bulfer, Stacie L; Weihl, Conrad C et al. (2014) Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol 426:2886-99|
|Goller, Carlos C; Arshad, Mehreen; Noah, James W et al. (2014) Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis. PLoS One 9:e96054|
|Flaherty, Daniel P; Simpson, Denise S; Miller, Melissa et al. (2014) Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett 24:3968-73|
|Mukherjee, Sourav; Weiner, Warren S; Schroeder, Chad E et al. (2014) Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication. ACS Chem Biol 9:2393-403|
|Chung, Dong-Hoon; Moore, Blake P; Matharu, Daljit S et al. (2013) A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus. Virol J 10:19|
|Sweeney, Noreena L; Shadrick, William R; Mukherjee, Sourav et al. (2013) Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. J Biol Chem 288:19949-57|
|Chou, Tsui-Fen; Li, Kelin; Frankowski, Kevin J et al. (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8:297-312|
|Coombs, Thomas C; Tanega, Cordelle; Shen, Min et al. (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett 23:3654-61|
|Zhang, Jintao; Huan, Jun (2013) Predicting drug-induced QT prolongation effects using multi-view learning. IEEE Trans Nanobioscience 12:206-13|
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