Abstract

E. Informatics CoreThe Informatics Core will provide for the data-capture and -analysis needs of each of the other BCSC Cores,including registration and tracking of stock-compound information, integration of data between compoundmanagement and high-throughput screening, tracking data-analysis procedures, basic cheminformatics needsfor follow-up chemistry, and deposit of high-quality data to PubChem.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HG005032-01
Application #
7695861
Study Section
Special Emphasis Panel (ZRG1-IFCN-K (52))
Project Start
2008-09-01
Project End
2014-05-31
Budget Start
2008-09-01
Budget End
2009-05-31
Support Year
1
Fiscal Year
2008
Total Cost
$2,568,900
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

McLellan, Catherine A; Vincent, Benjamin M; Solis, Norma V et al. (2018) Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. Nat Chem Biol 14:135-141
Sharabi, Kfir; Lin, Hua; Tavares, Clint D J et al. (2017) Selective Chemical Inhibition of PGC-1? Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell 169:148-160.e15
Wagner, Florence F; Bishop, Joshua A; Gale, Jennifer P et al. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol 11:1952-63
Zielonka, Jacek; Zielonka, Monika; VerPlank, Lynn et al. (2016) Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation. J Biol Chem 291:7029-44
de Waal, Luc; Lewis, Timothy A; Rees, Matthew G et al. (2016) Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol 12:102-8
Bageshwar, Umesh K; VerPlank, Lynn; Baker, Dwight et al. (2016) High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors. PLoS One 11:e0149659
Lessing, Derek; Dial, Thomas O; Wei, Chunyao et al. (2016) A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proc Natl Acad Sci U S A 113:14366-14371
Lewis, Timothy A; Sykes, David B; Law, Jason M et al. (2016) Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett 7:1112-1117
Lopez-Sambrooks, Cecilia; Shrimal, Shiteshu; Khodier, Carol et al. (2016) Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol 12:1023-1030
Bekendam, Roelof H; Bendapudi, Pavan K; Lin, Lin et al. (2016) A substrate-driven allosteric switch that enhances PDI catalytic activity. Nat Commun 7:12579

Showing the most recent 10 out of 46 publications