UNIT 4. INFORMATICS The Informatics Unit will be responsible for uploading data into PubChem and for providing and maintaining an effective data management system for data processing and for tracking compounds, assays, data and related information for the Burnham Center. By leveraging our pre-existing expertise and commercial data management technologies, we successfully built an effective and scalable system in the first year of MLSCN operation. The system has been extensively customized to handle the challenges arising from exponentially increasing volume, complexity, and diversity of data. In parallel, we have developed significant expertise and established the best practices for high-quality data transfer to PubChem. Altogether, Unit 4 has demonstrated advanced informatics capabilities and is ready to scale to the Production Phase of MLPCN.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HG005033-05
Application #
8379691
Study Section
Special Emphasis Panel (ZRG1-IFCN-K)
Project Start
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$782,053
Indirect Cost
$372,601
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Barak, Larry S; Bai, Yushi; Peterson, Sean et al. (2016) ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. ACS Chem Biol 11:1880-90
Roy, Sudeshna; Å ileikytÄ—, Justina; Neuenswander, Benjamin et al. (2016) N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore. ChemMedChem 11:283-8
Lv, Fengping; Li, Zhi-Fang; Hu, Wenhao et al. (2015) Small molecules enhance functional O-mannosylation of Alpha-dystroglycan. Bioorg Med Chem 23:7661-70
Tautz, Lutz; Senis, Yotis A; Oury, Cécile et al. (2015) Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy. Bioorg Med Chem 23:2786-97
Zou, Haixia; Limpert, Allison S; Zou, Jiwen et al. (2015) Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines. ACS Chem Neurosci 6:464-75
Rozanov, Dmitri; Cheltsov, Anton; Sergienko, Eduard et al. (2015) TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response. PLoS One 10:e0129566
Musumeci, Lucia; Kuijpers, Marijke J; Gilio, Karen et al. (2015) Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation 131:656-68
Alontaga, Aileen Y; Li, Yifei; Chen, Chih-Hong et al. (2015) Design of high-throughput screening assays and identification of a SUMO1-specific small molecule chemotype targeting the SUMO-interacting motif-binding surface. ACS Comb Sci 17:239-46
Roy, Sudeshna; Å ileikytÄ—, Justina; Schiavone, Marco et al. (2015) Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore. ChemMedChem 10:1655-71
Schreiber, Stuart L; Kotz, Joanne D; Li, Min et al. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell 161:1252-65

Showing the most recent 10 out of 61 publications