The African Collaborative Center for Microbiome and Genomics Research (ACCME) is a multi-country, multi-institutional collaborative research involving the Institutes of Human Virology and Genome Sciences at the University of Maryland;Department of Epidemiology and Public Health, School of Medicine University of Maryland, Baltimore;University of Abuja Teaching Hospital, Abuja, Nigeria and the Centre National d'Appui a la lutte centre la Maladie (CNAM) Mali. The objectives of the Center are to collaborate and implement high impact research programs characterizing the human microbiome and its role in health and disease. Specifically, ACCME links and leverages existing funded research and program activities at the collaborating institutions to study the interaction between vaginal microbiome, host genetic factors and molecular variants of Human Papilloma Virus (HPV) to determine correlates of viral persistence in the causal pathway of cervical cancer, a major cause of preventable mortality on the African continent. Recent studies by the investigative team, employing bacterial culture-independent, """"""""clone and sequence approach"""""""" employing 16S ribosomal RNA (rRNA) gene technologies have documented the complexity of vaginal microbiome and classified consistent microbial groupings termed """"""""community state types"""""""" that open a new window to understanding the role that the vaginal microbiome plays in cervical cancer pathogenesis. In addition to contributing to knowledge about vaginal microbiome, HPV persistence and cervical carcinogenesis, ACCME also develops capacity by training postdoctoral students to become the new generation of African scientific leaders while empowering hundreds of African scientists to conduct research in microbiome and genomics.

Public Health Relevance

The African Collaborative Center for Microbiome and Genomics Research (ACCME) leverages advanced research methods and technologies of the University of Maryland, Baltimore to build capacity, conduct training and research the role of vaginal microbiome in Human Papilloma Virus persistence and cervical carcinogenesis as a paradigmatic example of a high impact public health challenge that affects women's morbidity and mortality.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HG006947-02
Application #
8737743
Study Section
Special Emphasis Panel ()
Program Officer
Wiley, Kenneth L
Project Start
2013-09-19
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$965,000
Indirect Cost
$71,481
Name
Institute of Human Virology
Department
Type
DUNS #
850470568
City
Abuja
State
Country
Nigeria
Zip Code
90024-6
Oga, Emmanuel A; Brown, Jessica P; Brown, Clayton et al. (2016) Recurrence of cervical intraepithelial lesions after thermo-coagulation in HIV-positive and HIV-negative Nigerian women. BMC Womens Health 16:25
Oga, Emmanuel A; Schumaker, Lisa M; Alabi, Biodun Sulyman et al. (2016) Paucity of HPV-Related Head and Neck Cancers (HNC) in Nigeria. PLoS One 11:e0152828
Isa Modibbo, Fatima; Dareng, Eileen; Bamisaye, Patience et al. (2016) Qualitative study of barriers to cervical cancer screening among Nigerian women. BMJ Open 6:e008533
Jedy-Agba, E E; Dareng, E O; Adebamowo, S N et al. (2016) The burden of HPV associated cancers in two regions in Nigeria 2012-2014. Cancer Epidemiol 45:91-97
Odutola, Michael; Jedy-Agba, Elima E; Dareng, Eileen O et al. (2016) Burden of Cancers Attributable to Infectious Agents in Nigeria: 2012-2014. Front Oncol 6:216
Peprah, Emmanuel; Wiley, Ken; Troyer, Jennifer et al. (2016) Building a Platform to Enable NCD Research to Address Population Health in Africa: CVD Working Group Discussion at the Sixth H3Africa Consortium Meeting in Zambia. Glob Heart 11:165-70
Dareng, E O; Ma, B; Famooto, A O et al. (2016) Prevalent high-risk HPV infection and vaginal microbiota in Nigerian women. Epidemiol Infect 144:123-37
Jedy-Agba, Elima E; Oga, Emmanuel A; Odutola, Michael et al. (2015) Developing National Cancer Registration in Developing Countries - Case Study of the Nigerian National System of Cancer Registries. Front Public Health 3:186
Dareng, Eileen O; Jedy-Agba, Elima; Bamisaye, Patience et al. (2015) Influence of Spirituality and Modesty on Acceptance of Self-Sampling for Cervical Cancer Screening. PLoS One 10:e0141679
de Vries, Jantina; Tindana, Paulina; Littler, Katherine et al. (2015) The H3Africa policy framework: negotiating fairness in genomics. Trends Genet 31:117-9

Showing the most recent 10 out of 13 publications