The Virginia Comprehensive Sickle Cell Center will be organized administratively as a University Center at VCU, reporting to the Dean of the School of Medicine. But it also shows that the CSCC will also exist as a consortium of Academic Medical Centers for clinical research, consisting of providers interested in sickle cell disease. Research synergy will be emphasized, as will collaboration across disciplines and sites of activity. The CSCC Director, Dr. Wally Smith will oversee the entire Virginia Comprehensive Sickle Cell Center consortium. Dr. Smith will report to the Dean of the School of Medicine, Dr. Jerome Strauss. Dr. Imoigele Aisiku will assist Dr. Smith in oversight of the entire comprehensive center, and will chair CSCC meetings and assume operations in Dr. Smith's absence. Upon notice of award, the CSCC will apply to become a University Center. Dr. Smith will also serve as Clinical Core Director, overseeing consortium activities with three participating clinical referral sites at other academic medical centers, using monthly teleconferences, email, and a web site. Three research teams have already been formed, to address key issues in the overall center theme of novel sickle cell therapetuics. Research teams will hold weekly team meetings. Dr. Aisiku will lead the anti-sickling/ structural biology/vascular biology team. For the genetic therapy research team, Dr. Joyce Lloyd will serve as team leader. For the symptom therapy research team, Dr. John Roberts will serve as team leader. Dr. Kamar Godder will serve as Patient Services Core Director. All research team leaders and Core Directors will comprise the voting members of the CSCC Internal Advisory Board. Mr. Andrew Smithson will serve as CSCC Administrator, devoting 20% of his time to this project, as a nonvoting member of the CSCC Internal Advisory Board. Ms. Shannon Sekerak will oversee purchasing, monitor all grant expenses, and handle or oversee personnel administration. A fiscal tech TBN will generate and present to leadership financial spending and personnel reports. Costs for Web design cover 1) Information Architecture 2) Web Content Development 3) Web Design Development 4) Website Implementation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL090516-03
Application #
8261359
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
3
Fiscal Year
2011
Total Cost
$96,237
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Smith, Wally R; McClish, Donna K; Dahman, Bassam A et al. (2015) Daily home opioid use in adults with sickle cell disease: The PiSCES project. J Opioid Manag 11:243-53
Ameringer, Suzanne; Elswick Jr, R K; Smith, Wally (2014) Fatigue in adolescents and young adults with sickle cell disease: biological and behavioral correlates and health-related quality of life. J Pediatr Oncol Nurs 31:6-17
Redmond, Latasha C; Pang, Christopher J; Dumur, Catherine et al. (2014) Laser capture microdissection of embryonic cells and preparation of RNA for microarray assays. Methods Mol Biol 1092:43-60
Alsalman, Abdulkhaliq J; Smith, Wally R (2013) Expanding the framework of assessing adherence and medication-taking behavior. J Pain Palliat Care Pharmacother 27:114-24
Dampier, Carlton D; Smith, Wally R; Wager, Carrie G et al. (2013) IMPROVE trial: a randomized controlled trial of patient-controlled analgesia for sickle cell painful episodes: rationale, design challenges, initial experience, and recommendations for future studies. Clin Trials 10:319-31
Dampier, Carlton D; Wager, Carrie G; Harrison, Ryan et al. (2012) Impact of PCA strategies on pain intensity and functional assessment measures in adults with sickle cell disease during hospitalized vaso-occlusive episodes. Am J Hematol 87:E71-4
Pang, Christopher J; Lemsaddek, Wafaa; Alhashem, Yousef N et al. (2012) Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol 32:2628-44
Peters-Lawrence, Marlene H; Bell, Margaret C; Hsu, Lewis L et al. (2012) Clinical trial implementation and recruitment: lessons learned from the early closure of a randomized clinical trial. Contemp Clin Trials 33:291-7
Dampier, Carlton D; Smith, Wally R; Kim, Hae-Young et al. (2011) Opioid patient controlled analgesia use during the initial experience with the IMPROVE PCA trial: a phase III analgesic trial for hospitalized sickle cell patients with painful episodes. Am J Hematol 86:E70-3
Sogutlu, Aslihan; Levenson, James L; McClish, Donna K et al. (2011) Somatic symptom burden in adults with sickle cell disease predicts pain, depression, anxiety, health care utilization, and quality of life: the PiSCES project. Psychosomatics 52:272-9

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