Administration: The major role of the Administrative Core is to coordinate the various projects and core components and to provide specific administrative services to all projects to facilitate their scientific progress. The preparation of progress reports and continuation grants will be the responsibility of the Director, with considerable assistance by the Administrator. The former will be responsible for the scientific report while the latter will be responsible for the financial information. Financial management The administrator for the Program will be involved in the development of budgets. The administrator will meet with the Project Directors and Core Directors regularly to assess their budgetary needs and budgetary status. She will have responsibility for managing budgetary matters with Research Finance. Monthly reports will be provided. She will also serve to coordinate Consortium subcontractual arrangements with the Director of Research Administration in order to assure the timely dispersement of funds to other institutions to support subcontracts. Personnel management The administrator will also be the interface to the Department of Human Resources, the Education Office and, in some cases, the Harvard International Office, for matters relating to the hiring of personnel. Research technicians and research assistants will be recruited through the Department of Human Resources. Applicants will be reviewed by the Administrator and relevant key scientists. Once a final decision has been reached the formal hiring procedures will be the responsibility of the Administrator. Postdoctoral research fellows with either the PhD or MD degree will be recruited by placing advertisements in appropriate professional journals, on similar web sites and through contacts with colleagues. Other Centers participating in the TRC-THD program may be a good resource for these searches. Postdoctoral fellows receive appointments through the Department of Medicine and Harvard Medical School. The Center Administrator will assist the Director in obtaining these appointments for postdoctoral fellows. The Administrator will also assist the Director and other Project and Core leaders by coordinating annual evaluations, promotions. Assistance of foreign trainees with visa applications will be coordinated with the Education Office and the International Office of Harvard University.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-C (F1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Beth Israel Deaconess Medical Center
United States
Zip Code
Bowley, Sheryl R; Fang, Chao; Merrill-Skoloff, Glenn et al. (2017) Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation. Nat Commun 8:14151
Stopa, Jack D; Baker, Katherine M; Grover, Steven P et al. (2017) Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates. J Biol Chem 292:9063-9074
Stopa, Jack D; Neuberg, Donna; Puligandla, Maneka et al. (2017) Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation. JCI Insight 2:e89373
Flaumenhaft, R (2016) Probing for thiol isomerase activity in thrombi. J Thromb Haemost 14:1067-9
Galinski, Christine N; Zwicker, Jeffrey I; Kennedy, Daniel R (2016) Revisiting the mechanistic basis of the French Paradox: Red wine inhibits the activity of protein disulfide isomerase in vitro. Thromb Res 137:169-73
Schulman, Sol; Bendapudi, Pavan; Sharda, Anish et al. (2016) Extracellular Thiol Isomerases and Their Role in Thrombus Formation. Antioxid Redox Signal 24:1-15
Flaumenhaft, Robert; Furie, Bruce (2016) Vascular thiol isomerases. Blood 128:893-901
Bekendam, Roelof H; Bendapudi, Pavan K; Lin, Lin et al. (2016) A substrate-driven allosteric switch that enhances PDI catalytic activity. Nat Commun 7:12579
Flaumenhaft, Robert; Furie, Bruce; Zwicker, Jeffrey I (2015) Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler Thromb Vasc Biol 35:16-23
Sharda, Anish; Kim, Sarah H; Jasuja, Reema et al. (2015) Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome. Blood 125:1633-42

Showing the most recent 10 out of 17 publications