WU has historically showcased strengths in many core basic sciences that are highly relevant to current and future research in thrombosis and hemostasis, such as human genome sequencing, platelet function, protein trafficking, and nanotechnology, among others. More recently, and largely independently, WU investigators of widely varying clinical backgrounds have evolved into national leaders in the design and real world execution of pivotal clinical thrombosis trials that include translational elements and that offer complex methodological, regulatory, and enrollment challenges, among them three NHLBI-sponsored multicenter randomized trials: 1) the Genetics Informatics Trial (GIFT) (National Pl: Dr. Brian Gage, Department of Medicine, NCT01006733);2) the Clarification of Optimal Anticoagulation through Genetics (COAG) Trial (Central Core Laboratory Director: Dr. Charies Eby, Department of Pathology and Laboratory Medicine, NCT00839657);and 3) the Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) Trial (National PI: Dr. Suresh Vedantham, Mallinckrodt Institute of Radiology, NCT00790335). Of note, the ATTRACT Trial has been hailed as setting a new benchmark for the degree and quality of interdisciplinary collaboration, with WU's Coordinating Center serving as a collaborative nexus for >250 thrombosis investigators from interventional radiology, hematology, cardiovascular medicine, emergency medicine, vascular surgery, pulmonary medicine, economics, and biostatistics. The TRC-THD Program therefore presents an exciting and timely opportunity for WU to reach new heights of scientific accomplishment by evolving into a truly integrated thrombosis and hemostasis research center of excellence. The Coordinating Center, which will house WU's Administrative Core, will create a strong operational framework that ensures frequent interaction between outstanding laboratory scientists and clinical researchers with specialized expertise in expediting human studies, many of whom have not previously collaborated. An integrated WU Center, synergizing nationally-recognized strengths in basic and clinical investigation, will offer a compelling capability to advance human health through research in thrombosis and hemostasis.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZHL1-CSR-C)
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Washington University
Saint Louis
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Vemuri, Chandu; Upadhya, Gundumi A; Arif, Batool et al. (2018) Antithrombin Perfluorocarbon Nanoparticles Improve Renal Allograft Function in a Murine Deceased Criteria Donor Model. Transplant Direct 4:e384
Chinnaraj, Mathivanan; Chen, Zhiwei; Pelc, Leslie A et al. (2018) Structure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep 8:2945
Chakraborty, Pradipta; Acquasaliente, Laura; Pelc, Leslie A et al. (2018) Interplay between conformational selection and zymogen activation. Sci Rep 8:4080
Girard, T J; Grunz, K; Lasky, N M et al. (2018) Re-evaluation of mouse tissue factor pathway inhibitor and comparison of mouse and human tissue factor pathway inhibitor physiology. J Thromb Haemost 16:2246-2257
Wu, Xiaobo; Hutson, Irina; Akk, Antonina M et al. (2018) Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy. J Immunol 200:2786-2797
Sivaraja, Mohanram; Pozzi, Nicola; Rienzo, Matthew et al. (2018) Reversible covalent direct thrombin inhibitors. PLoS One 13:e0201377
Barranco-Medina, Sergio; Murphy, Mary; Pelc, Leslie et al. (2017) Rational Design of Protein C Activators. Sci Rep 7:44596
Liszewski, M Kathryn; Java, Anuja; Schramm, Elizabeth C et al. (2017) Complement Dysregulation and Disease: Insights from Contemporary Genetics. Annu Rev Pathol 12:25-52
Shen, Guomin; Cui, Weidong; Zhang, Hao et al. (2017) Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer. Nat Struct Mol Biol 24:69-76
Chakraborty, Pradipta; Di Cera, Enrico (2017) Induced Fit Is a Special Case of Conformational Selection. Biochemistry 56:2853-2859

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