Washington University Medical Center is well positioned to develop the next generation of translational researchers in the area of hemostatic and thrombotic disorders. WUMC has a long tradition of outstanding " hemostasis and thrombosis research that is epitomized by the example of Cari V. Moore, who founded the Division of Hematology in 1938 and was Chairman of Medicine from 1955-1972, and who was instrumental in making the Medical Center a focal point of basic and clinical research. Today, the institution remains outstanding in hemostasis and thrombosis research and has a superb infrastructure for clinical investigation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL112303-02
Application #
8464259
Study Section
Special Emphasis Panel (ZHL1-CSR-C)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$24,498
Indirect Cost
$6,915
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Pozzi, Nicola; Di Cera, Enrico (2014) Prothrombin structure: unanticipated features and opportunities. Expert Rev Proteomics 11:653-5
Pozzi, Nicola; Chen, Zhiwei; Pelc, Leslie A et al. (2014) The linker connecting the two kringles plays a key role in prothrombin activation. Proc Natl Acad Sci U S A 111:7630-5
Saini, Arun; Spinella, Philip C (2014) Management of anticoagulation and hemostasis for pediatric extracorporeal membrane oxygenation. Clin Lab Med 34:655-73
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Myerson, Jacob Wheatley; He, Li; Allen, John Stacy et al. (2014) Thrombin-inhibiting nanoparticles rapidly constitute versatile and detectable anticlotting surfaces. Nanotechnology 25:395101
Yu, Yi; Triebwasser, Michael P; Wong, Edwin K S et al. (2014) Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration. Hum Mol Genet 23:5283-93
Zhou, Hui-fang; Yan, Huimin; Pan, Hua et al. (2014) Peptide-siRNA nanocomplexes targeting NF-?B subunit p65 suppress nascent experimental arthritis. J Clin Invest 124:4363-74
Vogt, Austin D; Pozzi, Nicola; Chen, Zhiwei et al. (2014) Essential role of conformational selection in ligand binding. Biophys Chem 186:13-21
Pozzi, Nicola; Chen, Zhiwei; Gohara, David W et al. (2013) Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation. J Biol Chem 288:22734-44
Barranco-Medina, Sergio; Pozzi, Nicola; Vogt, Austin D et al. (2013) Histone H4 promotes prothrombin autoactivation. J Biol Chem 288:35749-57

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