The Clinical-Translational Informatics and Biorepository Core (CTIBC) will serve as a central repository of clinical data and biological specimens, including plasma and DNA collected from patients with hemophilia A. The CTIBC will serve as a resource to coordinate collection and storage of clinical data as well as plasma and DNA to support project 3 aim 3 and project 4 aim 1 and 2. Additionally, the CTIBC will serve as a major resource for the training core as a source of clinical data linked to biological specimens that can be used by trainees and young investigators for new clinical-translational research projects in hemostasis. Having high quality prospectively collected data linked to biological samples will provide a wealth of opportunity for clinical translational research performed by trainees participating in either the KL-2 Mentored Clinical Research Scholars Program or Master of Science in Clinical Research program.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HL112309-01
Application #
8392594
Study Section
Special Emphasis Panel (ZHL1-CSR-C (F1))
Project Start
2012-05-01
Project End
2017-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
1
Fiscal Year
2012
Total Cost
$315,410
Indirect Cost
$110,383
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Chao, B N; Baldwin, W H; Healey, J F et al. (2016) Characterization of a genetically engineered mouse model of hemophilia A with complete deletion of the F8 gene. J Thromb Haemost 14:346-55
Ciciliano, Jordan C; Sakurai, Yumiko; Myers, David R et al. (2015) Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach. Blood 126:817-24
Qiu, Yongzhi; Ciciliano, Jordan; Myers, David R et al. (2015) Platelets and physics: How platelets ""feel"" and respond to their mechanical microenvironment. Blood Rev 29:377-86
Kahle, Joerg; Orlowski, Aleksander; Stichel, Diana et al. (2015) Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. Thromb Haemost 113:396-405
Mannino, Robert G; Myers, David R; Ahn, Byungwook et al. (2015) ""Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions"". Sci Rep 5:12401
Zakas, P M; Vanijcharoenkarn, K; Markovitz, R C et al. (2015) Expanding the ortholog approach for hemophilia treatment complicated by factor VIII inhibitors. J Thromb Haemost 13:72-81

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