Abstract

ADMINSTRATIVE COORDINATING CENTER (ACC) Emory-Children's will serve as the Administrative Coordinating Center (ACC) for the TRC-THD Centers. The ACC will facilitate interactions between the TRC-THD Centers that are designed to identify ways in which the centers can collaborate, share information (and possibly specimens), and maximize resources. These Interactions will be accomplished by organizing Investigator and External Panel meetings, coordinating conference calls, and designing and maintaining a website for the TRC-THD program. This website will be developed in conjunction with the Research Health Sciences Information Technology Division and its affiliation with the Atlanta Clinical and Translational Science Institute. With oversight by the NHLBI, the Administrative Coordinating Center will bring together a large and multidisciplinary community of TRC-THD Centers that will support excellence in research in hemostasis and thrombosis by anticipating and allowing fluidity to accommodate changes and progress in the fleld. By providing a central administrative structure, the ACC will foster a unique collaborative research community during the course of the funding years and in the years beyond.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL112309-04
Application #
8845243
Study Section
Special Emphasis Panel (ZHL1-CSR-C)
Project Start
Project End
2016-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
4
Fiscal Year
2015
Total Cost
$125,398
Indirect Cost
$44,515

  Institution

Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Brown, Harrison C; Zakas, Philip M; George, Stephan N et al. (2018) Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A. Mol Ther Methods Clin Dev 9:57-69
Zhang, Yun; Qiu, Yongzhi; Blanchard, Aaron T et al. (2018) Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation. Proc Natl Acad Sci U S A 115:325-330
Healey, J F; Parker, E T; Lollar, P (2018) Identification of aggregates in therapeutic formulations of recombinant full-length factor VIII products by sedimentation velocity analytical ultracentrifugation. J Thromb Haemost 16:303-315
Batsuli, G; Ito, J; Mercer, R et al. (2018) Anti-C1 domain antibodies that accelerate factor VIII clearance contribute to antibody pathogenicity in a murine hemophilia A model. J Thromb Haemost 16:1779-1788
Qiu, Yongzhi; Ahn, Byungwook; Sakurai, Yumiko et al. (2018) Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease. Nat Biomed Eng 2:453-463
Sakurai, Yumiko; Hardy, Elaissa T; Ahn, Byungwook et al. (2018) A microengineered vascularized bleeding model that integrates the principal components of hemostasis. Nat Commun 9:509
Brockman, Joshua M; Blanchard, Aaron T; Pui-Yan Ma, Victor et al. (2018) Mapping the 3D orientation of piconewton integrin traction forces. Nat Methods 15:115-118
Qiu, Yongzhi; Tong, Sheng; Zhang, Linlin et al. (2017) Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions. Nat Commun 8:15594
Deng, W; Wang, Y; Druzak, S A et al. (2017) A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor. J Thromb Haemost 15:1867-1877
Mannino, Robert G; Santiago-Miranda, Adriana N; Pradhan, Pallab et al. (2017) 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro. Lab Chip 17:407-414

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