The Translational and Research Skills Development Core (Core D) will be the primary vehicle by which the University of Utah Molecular MedicineTranslational Research Center in Thrombosis (U2M2-TRCT) trains young investigators. Core D will take advantage of existing infrastructure at the University of Utah and, in doing so, will provide a unique training environment for MD, PhD, and MD-PhD scientists at various career stages. This includes utilization of the University of Utah Clinical Center in Translational Science (CCTS), four T32 programs, a HHMI med-to-grad PhD scientist training program, the MD-PhD program, and the Medical Student Summer research program. All of these programs are directed or co-directed by U2M2-TRCT investigators. Core D will use this infrastructure to rigorously prepare young investigators for bench to-bedside research careers related to metabolism and/or thrombosis. The Core provides an in-depth and cohesive education program for all types of young invesfigators. This curriculum includes specialized classes that focus on metabolism and thrombosis. Core D also includes individualized mentoring with U2M2-TRCT established scientists that will introduce young investigators to the ins-and-outs of basic and translational research. A primary objective of Core D will be to help young investigators generate preliminary data for competitive grant applications. In parallel, the young investigators will participate in grant writing workshops and research-in-progress sessions that provide a platform for presentation and critique of research plans. The U2M2-TRCT program already includes several young and emerging investigators who participated in preparing this submission. These investigators have previously trained with U2M2-TRCT senior scientists, have successfully applied and received young investigator awards, and are well on their way to independent research careers. Core D will continue to provide a fertile environment that fosters the development of these investigators and other MD, PhD, and MD-PhD trainees who will enter the program over the next several years.

Public Health Relevance

Patients with type 2 diabetes, obesity, or the metabolic syndrome are at increased risk for blood clots (thrombosis) caused by cells called platelets. Our studies will determine how metabolic factors in the blood and tissues (the metabolic milieu), such as high glucose and lipids, make platelets more prone to induce thrombosis, providing new insights into the treatment and management of diabetes and obesity.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL112311-03
Application #
8656423
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Manne, Bhanu K; Xiang, Shang Chun; Rondina, Matthew T (2017) Platelet secretion in inflammatory and infectious diseases. Platelets 28:155-164
Kapur, Rick; Kim, Michael; Rebetz, Johan et al. (2017) Low levels of interleukin-10 in patients with transfusion-related acute lung injury. Ann Transl Med 5:339
Rezania, Samin; Puskarich, Michael A; Petrusca, Daniela N et al. (2017) Platelet hyperactivation, apoptosis and hypercoagulability in patients with acute pulmonary embolism. Thromb Res 155:106-115
Stewart, Lauren K; Nordenholz, Kristen E; Courtney, Mark et al. (2017) Comparison of acute and convalescent biomarkers of inflammation in patients with acute pulmonary embolism treated with systemic fibrinolysis vs. placebo. Blood Coagul Fibrinolysis 28:675-680
Fidler, Trevor P; Middleton, Elizabeth A; Rowley, Jesse W et al. (2017) Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol 37:1628-1639
Rodrigues, Rosana S; Bozza, Fernando A; Hanrahan, Christopher J et al. (2017) 18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury. Nucl Med Biol 48:52-62
Fidler, Trevor P; Campbell, Robert A; Funari, Trevor et al. (2017) Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep 21:1705
Zeller Meidell, Krystin; Robinson, Ryan; Vieira-de-Abreu, Adriana et al. (2017) RGDfK-functionalized gold nanorods bind only to activated platelets. J Biomed Mater Res A 105:209-217
Michael, James V; Wurtzel, Jeremy G T; Mao, Guang Fen et al. (2017) Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood 130:567-580
Pannucci, Christopher J; Rondina, Matthew T (2017) Should we be following anti-factor Xa levels in patients receiving prophylactic enoxaparin perioperatively? Surgery 161:329-331

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