The mouse is the most commonly used animal in biomedical research comprising >90% of all animal experimentation. This mammalian species is often the prime choice to flesh out mechanisms of action of drugs and to establish biochemical signaling pathways prior to entering human trials. Directly relevant to PENTACON, mice were used to predict and then assign mechanistic understanding to all recognized features ? thrombosis, hypertension, heart failure, dysrhythmia ? of the cardiovascular hazard in humans taking COX-2 selective NSAIDs (1,2). More than 20 genetic mouse models that disrupt or perturb the COX biosyntheticresponse pathway have been developed by PENTACON members, a unique resource for use in this proposal.

Agency
National Institute of Health (NIH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL117798-03
Application #
8689166
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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