From the outset we have worked from the assumption that the day-to-day oversight and coordination necessary to keeping such a large, complex project as i2b2 running smoothly with the end goal in mind could not be the sole province of the PI. For this reason we established a management structure, including a dedicated team led by the Executive Director and co-PI (Churchill and Glaser) to oversee (and help correct course when necessary) the direction and progress of the research plan. A regular meeting strategy including weekly full day meetings of all the i2b2 core representatives and, most Importantly, those between Core 1 and 2 investigators and the DBP leaders enforced this. Given the success of these structures we Intend to maintain those as is. Because, at the time we were the only NCBC that addressed health records and discovery research, the outreach and support to a rapidly growing i2b2 academic users group became a welcome, if unanticipated Core 6 activity. This activity varied widely. It ranged from helping steer governance challenges (e.g. what kind of open source license), to managing the relationships between the academic implementations of i2b2 and a fast growing set of commercial and non-academic clinical research Implementations of i2b2. Consonant with the expanded open source community role of Core 3, this outwardly facing activity of Core 6 will also grow. Further, given the extensive set of collaborations between i2b2 and existing NCBCs the so-called """"""""big P"""""""" activities are anticipated to grow, especially given the Increased use of i2b2 technologies through many of these (and proposed) other NCBCs. Finally, the selection of the last DBP team, (DBP #3) in year 4 will be a strategically important process which Core 6 will help manage in consultation with our internal scientific advisory committee.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54LM008748-09
Application #
8382741
Study Section
Special Emphasis Panel (ZRG1-BST-K)
Project Start
Project End
Budget Start
2012-09-15
Budget End
2013-09-14
Support Year
9
Fiscal Year
2012
Total Cost
$375,122
Indirect Cost
$186,657
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Murphy, Shawn N; Avillach, Paul; Bellazzi, Riccardo et al. (2017) Combining clinical and genomics queries using i2b2 - Three methods. PLoS One 12:e0172187
Hundemer, Gregory L; Baudrand, Rene; Brown, Jenifer M et al. (2017) Renin Phenotypes Characterize Vascular Disease, Autonomous Aldosteronism, and Mineralocorticoid Receptor Activity. J Clin Endocrinol Metab 102:1835-1843
Nanba, Kazutaka; Vaidya, Anand; Williams, Gordon H et al. (2017) Age-Related Autonomous Aldosteronism. Circulation 136:347-355
Luo, Yuan; Uzuner, Özlem; Szolovits, Peter (2017) Bridging semantics and syntax with graph algorithms-state-of-the-art of extracting biomedical relations. Brief Bioinform 18:160-178
Bigdeli, T B; Ripke, S; Peterson, R E et al. (2017) Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry 7:e1074
Luo, Yuan; Szolovits, Peter (2016) Efficient Queries of Stand-off Annotations for Natural Language Processing on Electronic Medical Records. Biomed Inform Insights 8:29-38
Castro, V M; Kong, S W; Clements, C C et al. (2016) Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study. Transl Psychiatry 6:e708
Lin, Chen; Dligach, Dmitriy; Miller, Timothy A et al. (2016) Multilayered temporal modeling for the clinical domain. J Am Med Inform Assoc 23:387-95
Ananthakrishnan, Ashwin N; Cagan, Andrew; Cai, Tianxi et al. (2016) Identification of Nonresponse to Treatment Using Narrative Data in an Electronic Health Record Inflammatory Bowel Disease Cohort. Inflamm Bowel Dis 22:151-8
Corey, Kathleen E; Kartoun, Uri; Zheng, Hui et al. (2016) Using an Electronic Medical Records Database to Identify Non-Traditional Cardiovascular Risk Factors in Nonalcoholic Fatty Liver Disease. Am J Gastroenterol 111:671-6

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