Abstract

CORE 1: COMPUTATIONAL SCIENCE Although there Is a strong methodological component to core 1, the substrate for the work contemplated here - large-scale health systems with all their quirks, biases, and heterogeneity of practice - Is by Its nature resistant to standard analytical approaches. However possible, novel methodologies for interpreting data derived from these noisy systems must provide derived data that can be documented as useful to clinical researchers, as represented by the principal investigators of our

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54LM008748-10
Application #
8519538
Study Section
Special Emphasis Panel (ZRG1-BST-K)
Project Start
Project End
Budget Start
2013-09-15
Budget End
2014-09-14
Support Year
10
Fiscal Year
2013
Total Cost
$1,216,811
Indirect Cost
$127,364

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Yu, Zhi; Kim, Seoyoung C; Vanni, Kathleen et al. (2018) Association between inflammation and systolic blood pressure in RA compared to patients without RA. Arthritis Res Ther 20:107
Agniel, Denis; Kohane, Isaac S; Weber, Griffin M (2018) Biases in electronic health record data due to processes within the healthcare system: retrospective observational study. BMJ 361:k1479
Yu, Sheng; Ma, Yumeng; Gronsbell, Jessica et al. (2018) Enabling phenotypic big data with PheNorm. J Am Med Inform Assoc 25:54-60
Nanba, Kazutaka; Vaidya, Anand; Williams, Gordon H et al. (2017) Age-Related Autonomous Aldosteronism. Circulation 136:347-355
Kim, Youngjun; Riloff, Ellen; Meystre, Stéphane M (2017) Exploiting Unlabeled Texts with Clustering-based Instance Selection for Medical Relation Classification. AMIA Annu Symp Proc 2017:1060-1069
Bigdeli, T B; Ripke, S; Peterson, R E et al. (2017) Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry 7:e1074
Hundemer, Gregory L; Baudrand, Rene; Brown, Jenifer M et al. (2017) Renin Phenotypes Characterize Vascular Disease, Autonomous Aldosteronism, and Mineralocorticoid Receptor Activity. J Clin Endocrinol Metab 102:1835-1843
Luo, Yuan; Wang, Fei; Szolovits, Peter (2017) Tensor factorization toward precision medicine. Brief Bioinform 18:511-514
Luo, Yuan; Uzuner, Özlem; Szolovits, Peter (2017) Bridging semantics and syntax with graph algorithms-state-of-the-art of extracting biomedical relations. Brief Bioinform 18:160-178
Luo, Yuan (2017) Recurrent neural networks for classifying relations in clinical notes. J Biomed Inform 72:85-95

Showing the most recent 10 out of 312 publications