CORE 1: COMPUTATIONAL SCIENCE Although there Is a strong methodological component to core 1, the substrate for the work contemplated here - large-scale health systems with all their quirks, biases, and heterogeneity of practice - Is by Its nature resistant to standard analytical approaches. However possible, novel methodologies for interpreting data derived from these noisy systems must provide derived data that can be documented as useful to clinical researchers, as represented by the principal investigators of our

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54LM008748-10
Application #
8519538
Study Section
Special Emphasis Panel (ZRG1-BST-K)
Project Start
Project End
Budget Start
2013-09-15
Budget End
2014-09-14
Support Year
10
Fiscal Year
2013
Total Cost
$1,216,811
Indirect Cost
$127,364
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Ananthakrishnan, Ashwin N; Cheng, Alice; Cagan, Andrew et al. (2015) Mode of childbirth and long-term outcomes in women with inflammatory bowel diseases. Dig Dis Sci 60:471-7
Ananthakrishnan, Ashwin N; Cagan, Andrew; Cai, Tianxi et al. (2015) Colonoscopy is associated with a reduced risk for colon cancer and mortality in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 13:322-329.e1
Lu, Bing; Rho, Young Hee; Cui, Jing et al. (2014) Associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis. J Rheumatol 41:24-30
Mandl, Kenneth D; Kohane, Isaac S; McFadden, Douglas et al. (2014) Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture. J Am Med Inform Assoc 21:615-20
Ghebremariam, Yohannes T; Lee, Jerry C; LePendu, Paea et al. (2014) Response to letters regarding article, "unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine". Circulation 129:e428
Ananthakrishnan, Ashwin N; Cagan, Andrew; Gainer, Vivian S et al. (2014) Thromboprophylaxis is associated with reduced post-hospitalization venous thromboembolic events in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 12:1905-10
Brown, Jenifer M; Underwood, Patricia C; Ferri, Claudio et al. (2014) Aldosterone dysregulation with aging predicts renal vascular function and cardiovascular risk. Hypertension 63:1205-11
Dligach, Dmitriy; Bethard, Steven; Becker, Lee et al. (2014) Discovering body site and severity modifiers in clinical texts. J Am Med Inform Assoc 21:448-54
Luo, Yuan; Sohani, Aliyah R; Hochberg, Ephraim P et al. (2014) Automatic lymphoma classification with sentence subgraph mining from pathology reports. J Am Med Inform Assoc 21:824-32
Matsouaka, Roland A; Li, Junlong; Cai, Tianxi (2014) Evaluating marker-guided treatment selection strategies. Biometrics 70:489-99

Showing the most recent 10 out of 194 publications