The RCMI program provides universally accessible equipment, infrastructure and analysis essential to initiate and sustain research projects at Meharry. In this application, we will address continuity of services and efficiency of resource management by bringing all the supported core equipment and functions into one continuous space, which will be renovated. Therefore, we are also requesting funds to renovate this space. We will accomplish this goal through the following specific aims: 1) Co-localize and merge three independent cores (Molecular Biology, Morphology, Proteomics), and an animal imaging instrument into the research infrastructure core 2) Expand research services and analysis by continuing to support bioinformatics activity, adding health informatics, and increasing biostatistics support 3) Centrally manage the research infrastructure core facility (CRISALIS) to ensure appropriate tracking, billing, and grant attribution by users 4) Cross-train seven staff scientists and junior faculty broadly to provide continuous and uninterrupted service 5) Renovate 5,000 sq. ft. of space to accommodate the specialized scientific instruments and personnel. By accomplishing these specific aims, we will centralize operations, increase efficiencies and create a more robust infrastructure for research services and training. This enhanced, unified strategic direction and execution will allow for uniformity, prioritizing future directions, and increased productivity by reducing redundancies in previously separate operations. The transformation of the space and cores into a more efficient and highly integrated research services suite will lower the startup cost burden of the newly recruited faculty while also providing excellent service value for our existing researchers.!

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54MD007586-31
Application #
9449958
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
31
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Meharry Medical College
Department
Type
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Dong, Xin-Hong; Ho, Meng-Hsuan; Liu, Bindong et al. (2018) Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep 8:8812
Santos-Barriopedro, Irene; Bosch-Presegué, Laia; Marazuela-Duque, Anna et al. (2018) SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-?B pathway. Nat Commun 9:101
Tantawy, Mohammed N; Charles Manning, H; Peterson, Todd E et al. (2018) Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model. Mol Imaging Biol 20:200-204
Pajarillo, Edward; Johnson Jr, James; Kim, Judong et al. (2018) 17?-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology 65:280-288
Suman, Shankar; Rachakonda, Girish; Mandape, Sammed N et al. (2018) Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase. PLoS Negl Trop Dis 12:e0006792
Ignacio, Rosa Mistica C; Dong, Yuan-Lin; Kabir, Syeda M et al. (2018) CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget 9:9751-9765
Miner, Martin; Parish, Sharon J; Billups, Kevin L et al. (2018) Erectile Dysfunction and Subclinical Cardiovascular Disease. Sex Med Rev :
Balasubramaniam, Muthukumar; Zhou, Jing; Addai, Amma et al. (2018) PF74 Inhibits HIV-1 Integration by Altering The Composition of the Preintegration Complex. J Virol :
Morris, Matthew C; Marco, Miriam; Maguire-Jack, Kathryn et al. (2018) Connecting Child Maltreatment Risk With Crime and Neighborhood Disadvantage Across Time and Place: A Bayesian Spatiotemporal Analysis. Child Maltreat :1077559518814364
Mayo-Gamble, Tilicia L; Middlestadt, Susan E; Lin, Hsien-Chang et al. (2018) Identifying Factors Underlying the Decision for Sickle Cell Carrier Screening Among African Americans Within Middle Reproductive Age. J Genet Couns 27:1302-1311

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