The long-term goal of the Meharry Translational Research Center (MeTRC) is to establish a national model for clinical and translational health disparities research. MeTRC will synergize several ongoing research initiatives at Meharry supported by NCRR including Research Center in Minority Institutions, Center for AIDS Health Disparities Research, Center for Women's Health Research, Clinical Research Center, and Clinical Research Education and Career Development Program. Building on particular strengths of the research enterprise at Meharry, the focus of MeTRC will be on infectious disease, including HIV/AIDS, and women's health. An integrated program of translational research will be established that spans basic fundamental research to applied, participant-involved clinical studies. The short term goal is to transform the capacity and infrastructure for translational research at Meharry.
The specific aims are: 1. Develop an administrative infrastructure that will facilitate development and maintenance of an integrated and innovative translational and clinical research program (MeTRC) 2. Develop a technical and support infrastructure that will sustain a program of integrated translational and clinical research. 3. Establish a process to facilitate the collaborative interactions and communication between RCTR faculty and staff needed to sustain and grow an integrated program of innovative clinical and translational research. 4. Establish a pipeline of basic, translational, and clinical research that will sustain and grow the MeTRC program. 5. Significantly enhance the infrastructure for translational and clinical research by establishing a new Participant and Clinical Interactions Resource (PCIR). 6. Develop a multidisciplinary training and career development program in clinical and translational research that takes advantage of the infrastructure, programs, and faculty of RCTR. 7. Engage and enhance an existing program created under the Vanderbilt-Meharry CTSA Focused Partnership to facilitate processes and partnerships in community-based clinical and translational research 8. Develop and implement a plan for self-evaluation of short-term and long-term RCTR goals including implementation and tracking of program activities.
The MeTRC environment will accelerate progress in the bench-to-bedside-to-community research enterprise, bi-directionally, as measured by peer-reviewed publications, increased internal and external collaborations including community partnerships, and improved health outcomes. Research activities will principally focus on infectious diseases in women including HIV/AIDS.
|Morris, Matthew C; Kouros, Chrystyna D; Janecek, Kim et al. (2017) Community-level moderators of a school-based childhood sexual assault prevention program. Child Abuse Negl 63:295-306|
|Ho, Meng-Hsuan; Lamont, Richard J; Xie, Hua (2017) Identification of Streptococcus cristatus peptides that repress expression of virulence genes in Porphyromonas gingivalis. Sci Rep 7:1413|
|Halpern, Leslie R; Shealer, Malcolm L; Cho, Rian et al. (2017) Influence of Intimate Partner Violence (IPV) Exposure on Cardiovascular and Salivary Biosensors: Is There a Relationship? J Natl Med Assoc 109:252-261|
|Dash, Sabyasachi; Balasubramaniam, Muthukumar; Rana, Tanu et al. (2017) Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. eNeuro 4:|
|Lu, W; Liu, S; Li, B et al. (2017) SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene 36:1364-1373|
|Borza, Dorin-Bogdan (2017) Glomerular basement membrane heparan sulfate in health and disease: A regulator of local complement activation. Matrix Biol 57-58:299-310|
|Aronoff, David M; Correa, Hernan; Rogers, Lisa M et al. (2017) Placental pericytes and cytomegalovirus infectivity: Implications for HCMV placental pathology and congenital disease. Am J Reprod Immunol 78:|
|Ho, Meng-Hsuan; Lamont, Richard J; Xie, Hua (2017) A novel peptidic inhibitor derived from Streptococcus cristatus ArcA attenuates virulence potential of Porphyromonas gingivalis. Sci Rep 7:16217|
|Uzhachenko, Roman; Boyd, Kelli; Olivares-Villagomez, Danyvid et al. (2017) Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) 9:627-649|
|Balasubramaniam, Muthukumar; Davids, Benem; Addai, Amma B et al. (2017) Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes. J Vis Exp :|
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