The Mid-South Transdisciplinary Collaborative Center for Health Disparities Research (Mid-South TCC), proposed by the University of Alabama at Birmingham, seeks to reduce the disparities in chronic disease burden experienced by African Americans in three Mid-South states (Alabama, Louisiana, and Mississippi), expand to another three Mid-South states (Arkansas, Tennessee, and Kentucky) and then nationally. The targeted Mid-South geographic area includes the most impoverished rural counties and inner-city communities in the nation, carrying exceptionally high burden of obesity, chronic diseases, and high mortality rates from these conditions. Our goal is to address the social determinants that interplay to impact a person's health and produce disparate health outcomes of minority populations. Specifically, we will focus on pathways to obesity and chronic illness and the mechanisms connecting these pathways to health disparities throughout the life-course. Our ultimate goal as a Mid-South TCC is to investigate all social, economic, cultural, and environmental factors driving and sustaining health disparities in obesity and chronic illnesses across the lifespan, and develop and implement interventions to ameliorate such disparities. This goal will be achieved through the following specific aims:
Aim 1. Conduct a one-year planning phase to: Solidify and expand the existing multi-sector Mid-South coalition in order to establish a regional infrastructure that will support the proposed research, implementation, and dissemination activities;Conduct a comprehensive assessment to identify existing relevant research, outreach capacities, policies and socioeconomic contexts, as well as barriers and needs unique to the targeted areas and population;Engage additional academic, community, and organizational/institutional partners and agencies to fill identified gaps;Identify areas of research to be developed and finalize procedures for pilot research projects;Develop a detailed plan and timelines for the program implementation.
Aim 2. Develop and implement a collaborative research program of regional research sub-projects;Establish 3 shared cores to support all Mid-South TCC research: Social Determinants of Health Measurement Core, Biostatistics/Study Design Core, and Academic-Community Engagement Core.
Aim 4. Implement a pilot project program, including a career development component;
Aim 5. Evaluate the research, implementation, and dissemination activities of the TCC.
The Mid-South Transdisciplinary Collaborative Center for Health Disparities Research (Mid-South TCC) seeks to reduce the disparities in chronic disease burden experienced by African Americans in six Mid-South states. Our goal is to address the social determinants that interplay to impact a person's health and produce disparate health outcomes of minority populations. We will focus on pathways to obesity and chronic illness and the mechanisms connecting these pathways to health disparities throughout the life-course.
|Booth 3rd, John N; Diaz, Keith M; Seals, Samantha R et al. (2016) Masked Hypertension and Cardiovascular Disease Events in a Prospective Cohort of Blacks: The Jackson Heart Study. Hypertension 68:501-10|
|Tabatabai, Mohammad A; Kengwoung-Keumo, Jean-Jacques; Oates, Gabriela R et al. (2016) Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis. PLoS One 11:e0162949|
|Serrano-Gomez, Silvia Juliana; Sanabria-Salas, Maria Carolina; HernÃ¡ndez-Suarez, Gustavo et al. (2016) High prevalence of luminal B breast cancer intrinsic subtype in Colombian women. Carcinogenesis 37:669-76|
|Kepper, M; Tseng, T-S; Volaufova, J et al. (2016) Pre-school obesity is inversely associated with vegetable intake, grocery stores and outdoor play. Pediatr Obes 11:e6-8|
|Joseph, Ann Mary; Srivastava, Ratika; Zabaleta, Jovanny et al. (2016) Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects. Cancer Immunol Res 4:708-16|
|Loupe, Jacob M; Miller, Patrick J; Bonner, Benjamin P et al. (2016) Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects. Oncotarget :|
|Loupe, J M; Miller, P J; Bonner, B P et al. (2016) Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion. Oncogenesis 5:e246|
|Kepper, Maura; Broyles, Stephanie; Scribner, Richard et al. (2016) Parental Perceptions of the Social Environment Are Inversely Related to Constraint of Adolescents' Neighborhood Physical Activity. Int J Environ Res Public Health 13:|
|Booth 3rd, John N; Redmond, Nicole; Sims, Mario et al. (2016) The association of reduced lung function with blood pressure variability in African Americans: data from the Jackson Heart Study. BMC Cardiovasc Disord 16:6|
|Coulon, Sara J; Velasco-Gonzalez, Cruz; Scribner, Richard et al. (2016) Racial differences in neighborhood disadvantage, inflammation and metabolic control in black and white pediatric type 1 diabetes patients. Pediatr Diabetes :|
Showing the most recent 10 out of 26 publications