Yeast is widely used to investigate basic biological processes and a plethora of powerful tools are already developed. Conservation of function from this experimentally tractable eukaryotic organism to man sets the stage for basic discoveries that are relevant to all living organisms. A survey of PubChem screening projects shows that only a handful of large scale yeast HT screens (>10,000 molecules) have been completed. Most of these involve a simple viability endpoint. We see an opportunity to leverage extant and emerging yeast technologies with our expertise in HT flow cytometry to create a sophisticated platform for HTS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54MH084690-04S2
Application #
8704043
Study Section
Special Emphasis Panel (ZRG1-IFCN-K)
Project Start
2008-09-01
Project End
2014-05-31
Budget Start
2013-08-19
Budget End
2014-05-31
Support Year
4
Fiscal Year
2013
Total Cost
$799,999
Indirect Cost
$214,199
Name
University of New Mexico Health Sciences Center
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Hong, Lin; Chavez, Stephanie; Smagley, Yelena et al. (2016) Relationship of light scatter change and Cdc42-regulated actin status. Cytometry B Clin Cytom 90:499-505
Yang, Jeremy J; Ursu, Oleg; Lipinski, Christopher A et al. (2016) Badapple: promiscuity patterns from noisy evidence. J Cheminform 8:29
Zahoránszky-Kőhalmi, Gergely; Bologa, Cristian G; Oprea, Tudor I (2016) Impact of similarity threshold on the topology of molecular similarity networks and clustering outcomes. J Cheminform 8:16
Wu, Yang; Stauffer, Shaun R; Stanfield, Robyn L et al. (2016) Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. J Biomol Screen 21:74-87
Sykes, David B; Kfoury, Youmna S; Mercier, François E et al. (2016) Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell 167:171-186.e15
Guo, Yuna; Kenney, S Ray; Cook, Linda et al. (2015) A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients. Clin Cancer Res 21:5064-72
Magana, Maria; Ioannidis, Anastasios; Magiorkinis, Emmanouil et al. (2015) Therapeutic options and emerging alternatives for multidrug resistant staphylococcal infections. Curr Pharm Des 21:2058-72
Schreiber, Stuart L; Kotz, Joanne D; Li, Min et al. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell 161:1252-65
Edwards, Bruce S; Sklar, Larry A (2015) Flow Cytometry: Impact on Early Drug Discovery. J Biomol Screen 20:689-707
Guo, Yuna; Kenney, S Ray; Muller, Carolyn Y et al. (2015) R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. Mol Cancer Ther 14:2215-27

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