Yeast is widely used to investigate basic biological processes and a plethora of powerful tools are already developed. Conservation of function from this experimentally tractable eukaryotic organism to man sets the stage for basic discoveries that are relevant to all living organisms. A survey of PubChem screening projects shows that only a handful of large scale yeast HT screens (>10,000 molecules) have been completed. Most of these involve a simple viability endpoint. We see an opportunity to leverage extant and emerging yeast technologies with our expertise in HT flow cytometry to create a sophisticated platform for HTS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54MH084690-04S2
Application #
8704043
Study Section
Special Emphasis Panel (ZRG1-IFCN-K)
Project Start
2008-09-01
Project End
2014-05-31
Budget Start
2013-08-19
Budget End
2014-05-31
Support Year
4
Fiscal Year
2013
Total Cost
$799,999
Indirect Cost
$214,199
Name
University of New Mexico Health Sciences Center
Department
Type
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
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Pinilla, Clemencia; Edwards, Bruce S; Appel, Jon R et al. (2013) Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. Mol Pharmacol 84:314-24
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