Yeast is widely used to investigate basic biological processes and a plethora of powerful tools are already developed. Conservation of function from this experimentally tractable eukaryotic organism to man sets the stage for basic discoveries that are relevant to all living organisms. A survey of PubChem screening projects shows that only a handful of large scale yeast HT screens (>10,000 molecules) have been completed. Most of these involve a simple viability endpoint. We see an opportunity to leverage extant and emerging yeast technologies with our expertise in HT flow cytometry to create a sophisticated platform for HTS.
| Palsuledesai, Charuta C; Surviladze, Zurab; Waller, Anna et al. (2018) Activation of Rho Family GTPases by Small Molecules. ACS Chem Biol 13:1514-1524 |
| Bredemeyer, Andrea L; Edwards, Bruce S; Haynes, Mark K et al. (2018) High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining. SLAS Discov 23:624-633 |
| Wu, Yang; Stauffer, Shaun R; Stanfield, Robyn L et al. (2016) Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. J Biomol Screen 21:74-87 |
| Yang, Jeremy J; Ursu, Oleg; Lipinski, Christopher A et al. (2016) Badapple: promiscuity patterns from noisy evidence. J Cheminform 8:29 |
| Zahoránszky-K?halmi, Gergely; Bologa, Cristian G; Oprea, Tudor I (2016) Impact of similarity threshold on the topology of molecular similarity networks and clustering outcomes. J Cheminform 8:16 |
| Hong, Lin; Chavez, Stephanie; Smagley, Yelena et al. (2016) Relationship of light scatter change and Cdc42-regulated actin status. Cytometry B Clin Cytom 90:499-505 |
| Sykes, David B; Kfoury, Youmna S; Mercier, François E et al. (2016) Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell 167:171-186.e15 |
| Holmes, Ann R; Cardno, Tony S; Strouse, J Jacob et al. (2016) Targeting efflux pumps to overcome antifungal drug resistance. Future Med Chem 8:1485-501 |
| Zhao, Ziyan; Haynes, Mark K; Ursu, Oleg et al. (2015) A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants. J Biomol Screen 20:359-71 |
| Schreiber, Stuart L; Kotz, Joanne D; Li, Min et al. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell 161:1252-65 |
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