Assay Development, Adaptation and Implementation (DAI)Core Core Functions 1. Evaluate the suitability of JHICC capability in performing assays assigned by NIH and MLPCN 2. Manage the assay transfer 3. Determine milestones, schedule and deliverables to formulate compound probe development plan (CPDP) 4. Adapt and optimize assays transferred from assay providers 5. Determine and develop secondary assays 6. Prepare and finalize assessment of HTS-readiness 7. Maintain a steady supply of HTS-feasible or HTS-ready assays in pipeline.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54MH084691-04S1
Application #
8414254
Study Section
Special Emphasis Panel (ZRG1-IFCN-K)
Project Start
Project End
2013-11-04
Budget Start
2011-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$100,001
Indirect Cost
$38,272
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Yu, Hai-bo; Zou, Bei-yan; Wang, Xiao-liang et al. (2016) Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay. Acta Pharmacol Sin 37:111-23
Sun, Han; Luo, Liqun; Lal, Bachchu et al. (2016) A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun 7:10339
Wen, Wandong; Wang, Yan; Li, Zhe et al. (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10:57-61
Yu, Haibo; Zou, Beiyan; Wang, Xiaoliang et al. (2015) Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels. Br J Pharmacol 172:3370-82
Li, Weiqiang; Koutmou, Kristin S; Leahy, Daniel J et al. (2015) Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1. J Biol Chem 290:18904-13
Zhu, Yingmin; Lu, Yungang; Qu, Chunrong et al. (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol 172:3495-509
Peters, Christian J; Yu, Haibo; Tien, Jason et al. (2015) Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A 112:3547-52
Zhang, Hongkang; Zou, Beiyan; Du, Fang et al. (2015) Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5. Mol Pharmacol 87:207-17
Du, Fang; Babcock, Joseph J; Yu, Haibo et al. (2015) Global analysis reveals families of chemical motifs enriched for HERG inhibitors. PLoS One 10:e0118324
Schreiber, Stuart L; Kotz, Joanne D; Li, Min et al. (2015) Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell 161:1252-65

Showing the most recent 10 out of 57 publications