This proposal has been prepared in response to RFA NS-99-001, and describes a Specialized Neuroscience Research Program for this Minority Institution. The Bekesy Laboratory of Neurobiology provides an appropriate site for this SNRP and would be greatly strengthened by the requested award. Three junior faculty have been selected, who have developed collaborative proposals involving an investigator at a research- intensive institution. Project 1- involves characterization of novel neuroactive compounds from Cnidaria venoms. This work will be carried out in collaboration with investigators from Johns Hopkins University who are well-known for their work in this area. Project 2- asks whether cytotoxic T lymphocytes located within the central nervous system lead to selection on neurovirulent strains of HIV-1 thus initiating AIDS dementia complex as a delayed result of this selection process. This work will be carried out in collaboration with an experienced investigator at the University of Washington, Seattle. Project 3- seeks to characterize the microbial agent responsible for a form of encephalomyelitis found in a specific Siberian population. However, prevalence is the same in-migrants as in the native population. This work will be carried out in collaboration with an NINDS Intramural investigator experienced in study of infectious diseases. Internal and External Advisory committees have been established to further assist the selected faculty in developing their independent neuroscience research careers. This award will substantially improve opportunities for underserved minorities to obtain high-quality research training in neurosciences at this institution.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54NS039406-03S1
Application #
6502280
Study Section
Special Emphasis Panel (ZNS1 (01))
Program Officer
Dowling, Gayathri
Project Start
1999-09-30
Project End
2004-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
3
Fiscal Year
2001
Total Cost
$28,778
Indirect Cost
Name
University of Hawaii
Department
Biology
Type
Organized Research Units
DUNS #
121911077
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Wilcox, Christie L; Headlam, Jasmine L; Doyle, Thomas K et al. (2017) Assessing the Efficacy of First-Aid Measures in Physalia sp. Envenomation, Using Solution- and Blood Agarose-Based Models. Toxins (Basel) 9:
Yanagihara, Angel Anne; Wilcox, Christie L (2017) Cubozoan Sting-Site Seawater Rinse, Scraping, and Ice Can Increase Venom Load: Upending Current First Aid Recommendations. Toxins (Basel) 9:
Doyle, Thomas K; Headlam, Jasmine L; Wilcox, Christie L et al. (2017) Evaluation of Cyanea capillata Sting Management Protocols Using Ex Vivo and In Vitro Envenomation Models. Toxins (Basel) 9:
Yanagihara, Angel A; Wilcox, Christie; King, Rebecca et al. (2016) Experimental Assays to Assess the Efficacy of Vinegar and Other Topical First-Aid Approaches on Cubozoan (Alatina alata) Tentacle Firing and Venom Toxicity. Toxins (Basel) 8:
Cloak, Christine C; Alicata, Daniel; Ernst, Thomas M et al. (2015) Psychiatric Symptoms, Salivary Cortisol and Cytokine Levels in Young Marijuana Users. J Neuroimmune Pharmacol 10:380-90
Chiaverano, Luciano M; Holland, Brenden S; Crow, Gerald L et al. (2013) Long-term fluctuations in circalunar Beach aggregations of the box jellyfish Alatina moseri in Hawaii, with links to environmental variability. PLoS One 8:e77039
Chang, Linda; Cloak, Christine C; Jiang, Caroline S et al. (2012) Lower glial metabolite levels in brains of young children with prenatal nicotine exposure. J Neuroimmune Pharmacol 7:243-52
Yanagihara, Angel A; Shohet, Ralph V (2012) Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice. PLoS One 7:e51368
Cloak, Christine C; Alicata, Daniel; Chang, Linda et al. (2011) Age and sex effects levels of choline compounds in the anterior cingulate cortex of adolescent methamphetamine users. Drug Alcohol Depend 119:207-15
Pitts, Matthew W; Takahashi, Lorey K (2011) The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory. Neurobiol Learn Mem 95:86-91

Showing the most recent 10 out of 47 publications