The administrative core of the Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center will coordinate the activities within and outside the Center as well as promote an interactive and collaborative research environment. The responsibilities of Core A include the following: organization of the flow of project information, distribution of research effort, allocation of budgetary and other resources, preparing annual budgets and projections, scheduling and facilitating regular Muscle Disease Neuropathology Conference meetings, and consulting the Dean regarding progress, scientific direction, administrative issues and concerns, and future plans. The scientific responsibilities of Core A include the following: scientific integration, coordination, and direction of research projects as needed, consultation with advisors and consultants concerning importance and progress of the research as it relates to other current and developing muscular dystrophy research, identifying seminar speakers and coordinating their participation and contributions to the Center, and holding an annual retreat for the Center Investigators. This core will also facilitate expansion of our collaboration with national and international leaders in the field of congenital/limbgirdle muscular dystrophy. The Core A Administrator coordinates an annual open house for the Muscular Dystrophy Association located in Cedar Rapids, lowa which hosts seminars for approximately 100 patients/families to discuss current and upcoming research and advancements in muscular dystrophy. The Administrator is also responsible for coordinating the Wellstone Steering Committee Face to Face Meeting when hosted by the University of lowa, coordinating meetings among Core Directors and Project Leaders, and coordinating patient/family tours.

Public Health Relevance

The administrative core of our MDCRC renewal will coordinate the overall mission of the MDCRC by providing essential administrative support (for example tracking the budget and coordinating patient visits) for the two two projects and other cores in order to accelerate the tempo of discovery in preclinical translational research and the achievement of clinical trial readiness.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS053672-10
Application #
8675963
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Briggs, David C; Yoshida-Moriguchi, Takako; Zheng, Tianqing et al. (2016) Structural basis of laminin binding to the LARGE glycans on dystroglycan. Nat Chem Biol 12:810-4
de Greef, Jessica C; Hamlyn, Rebecca; Jensen, Braden S et al. (2016) Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the γ-sarcoglycan-null mouse. Hum Mol Genet 25:1357-69
Jerber, Julie; Zaki, Maha S; Al-Aama, Jumana Y et al. (2016) Biallelic Mutations in TMTC3, Encoding a Transmembrane and TPR-Containing Protein, Lead to Cobblestone Lissencephaly. Am J Hum Genet 99:1181-1189
Lawlor, Michael W; Beggs, Alan H; Buj-Bello, Ana et al. (2016) Skeletal Muscle Pathology in X-Linked Myotubular Myopathy: Review With Cross-Species Comparisons. J Neuropathol Exp Neurol 75:102-10
Praissman, Jeremy L; Willer, Tobias; Sheikh, M Osman et al. (2016) The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition. Elife 5:
Agre, Peter; Bertozzi, Carolyn; Bissell, Mina et al. (2016) Training the next generation of biomedical investigators in glycosciences. J Clin Invest 126:405-8
Turk, Rolf; Hsiao, Jordy J; Smits, Melinda M et al. (2016) Molecular Signatures of Membrane Protein Complexes Underlying Muscular Dystrophy. Mol Cell Proteomics 15:2169-85
Rader, Erik P; Turk, Rolf; Willer, Tobias et al. (2016) Role of dystroglycan in limiting contraction-induced injury to the sarcomeric cytoskeleton of mature skeletal muscle. Proc Natl Acad Sci U S A 113:10992-7
Jensen, Braden S; Willer, Tobias; Saade, Dimah N et al. (2015) GMPPB-Associated Dystroglycanopathy: Emerging Common Variants with Phenotype Correlation. Hum Mutat 36:1159-63
Luo, Sushan; Zhu, Wenhua; Yue, Dongyue et al. (2015) Muscle pathology and whole-body MRI in a polyglucosan myopathy associated with a novel glycogenin-1 mutation. Neuromuscul Disord 25:780-5

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