Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54NS058183-06
Application #
8209411
Study Section
Special Emphasis Panel (ZRG1-MDCN-J (54))
Project Start
Project End
Budget Start
2011-09-30
Budget End
2012-08-31
Support Year
6
Fiscal Year
2011
Total Cost
$267,082
Indirect Cost
Name
U.S. Army Medical Research Institute Chem Def
Department
Type
DUNS #
168812329
City
Aberdeen Proving Ground
State
MD
Country
United States
Zip Code
21010
Ashani, Yacov; Leader, Haim; Aggarwal, Nidhi et al. (2016) In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications. Chem Biol Interact 259:252-256
Smith, Carl D; Wright, Linnzi K M; Garcia, Gregory E et al. (2015) Hormone-dependence of sarin lethality in rats: Sex differences and stage of the estrous cycle. Toxicol Appl Pharmacol 287:253-7
Magliery, Thomas J (2015) Protein stability: computation, sequence statistics, and new experimental methods. Curr Opin Struct Biol 33:161-8
Ben-David, Moshe; Sussman, Joel L; Maxwell, Christopher I et al. (2015) Catalytic stimulation by restrained active-site floppiness--the case of high density lipoprotein-bound serum paraoxonase-1. J Mol Biol 427:1359-74
Schneider, Jeannine D; Castilho, Alexandra; Neumann, Laura et al. (2014) Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue. Biotechnol J 9:501-10
Dwyer, Mary; Javor, Sacha; Ryan, Daniel A et al. (2014) Novel human butyrylcholinesterase variants: toward organophosphonate detoxication. Biochemistry 53:4476-87
Rockah-Shmuel, Liat; Tawfik, Dan S; Goldsmith, Moshe (2014) Generating targeted libraries by the combinatorial incorporation of synthetic oligonucleotides during gene shuffling (ISOR). Methods Mol Biol 1179:129-37
Li, Bin; Duysen, Ellen G; Froment, Marie-Thérèse et al. (2013) Polyclonal antibody to soman-tyrosine. Chem Res Toxicol 26:584-92
Jiang, Wei; Cashman, John R; Nachon, Florian et al. (2013) Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond. Toxicol Sci 132:390-8
Luechapanichkul, Rinrada; Chen, Xianwen; Taha, Hashem A et al. (2013) Specificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes. J Biol Chem 288:6498-510

Showing the most recent 10 out of 48 publications