In this new application, the Morehouse School of Medicine Neuroscience Institute is requesting funds to consolidate a program in Circadian Rhythms and Sleep Disorders (CRSD) that was established within the last two years. The CRSD Program is headed by Dr. Gianluca Tosini, an established investigator in the field of circadian rhythms. The current proposal consists of projects from 2 recently-recruited young investigators (Drs. Davidson and Paul) and 1 previously-funded investigator (Dr. Fukuhara). All projects build on the impressive advances of our understanding of the molecular components of the master circadian pacemaker and the interrelationships with peripheral circadian oscillators. All three projects have strong translational components and have direct relevance to a number of disorders that disproportionately affect minority populations. Dr. Davidson's research program (Project # 1) will investigate the consequence of changing lighting schedules (as might occur as a result of shift-work and jet-lag) on the health of mice. Dr. Fukuhara's research program (Project # 2) is centered on the relationships between mood disorders and misalignment of circadian rhythms. Dr. Paul's research program (Project # 3) will investigate sleep in a series of genetically altered mice. Another program -The Neuroprotection, Neurorepair and Stroke Program - headed by Dr. Byron Ford, has 2 R01 holders, is not requesting funds, but will make intellectual contributions towards the maintenance of a vibrant research environment within the Neuroscience Institute. In addition to requesting funds for the three projects listed above, the proposal requests funds for an administrative core and two research cores - Cell and Molecular Biology Core and Imaging and Microscopy Core - that will, in a cost-effective manner, support the science within the projects. Finally, a Training and Knowledge Transfer Core is requesting funds to continue a highly-successful Summer Research Program for undergraduates and medical students and a seminar series to keep investigators abreast of research from leading investigators. Our goal is to increase the number of investigators at MSM who are conducting competitive research at the R01 level and the pool of students from under-represented populations who are pursuing a career in the field of Neuroscience.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZNS1-SRB-R (28))
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Gordon, Alfred W
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Morehouse School of Medicine
Anatomy/Cell Biology
Schools of Medicine
United States
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Azzi, Abdelhalim; Evans, Jennifer A; Leise, Tanya et al. (2017) Network Dynamics Mediate Circadian Clock Plasticity. Neuron 93:441-450
Ehlen, J Christopher; Brager, Allison J; Baggs, Julie et al. (2017) Bmal1 function in skeletal muscle regulates sleep. Elife 6:
Reynolds, James P; Jimenez-Mateos, Eva M; Cao, Li et al. (2017) Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury. Neurochem Res 42:2033-2054
Simmons, Lauren J; Surles-Zeigler, Monique C; Li, Yonggang et al. (2016) Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. J Neuroinflammation 13:237
White, Todd E; Surles-Zeigler, Monique C; Ford, Gregory D et al. (2016) Bilateral gene interaction hierarchy analysis of the cell death gene response emphasizes the significance of cell cycle genes following unilateral traumatic brain injury. BMC Genomics 17:130
Reynolds, James P; Miller-Delaney, Suzanne F C; Jimenez-Mateos, Eva M et al. (2015) Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning. Front Neurol 6:46
Evans, Jennifer A; Suen, Ting-Chung; Callif, Ben L et al. (2015) Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body. BMC Biol 13:43
Rahman, Shadab A; Castanon-Cervantes, Oscar; Scheer, Frank A J L et al. (2015) Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans. Brain Behav Immun 47:4-13
Evans, Jennifer A; Leise, Tanya L; Castanon-Cervantes, Oscar et al. (2015) Neural correlates of individual differences in circadian behaviour. Proc Biol Sci 282:
Meller, Robert; Pearson, Andrea; Simon, Roger P (2015) Dynamic changes in DNA methylation in ischemic tolerance. Front Neurol 6:102

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