The Genetic and Statistical Analysis Core (GSAC) of the Brain Vascular Malformation Consortium (BVMC) is a centralized resource that provides data management statistical analysis and genetics services to all BVMC investigators. The GSAC is available to BVMC investigators for (a) managing and checking the flow of information into the database resources;(b) tracking specimens;(c) genetic analyses;and (d) providing datasets for statistical analysis and support for their analyses. All projects, including pilot projects and trainees, will use this Core. The GSAC has four specific aims:
Aim 1 : collaborate on statistical and genetic aspects of study design;
Aim 2 : maintain a data management and sample tracking system;
Aim 3 : periderm genotyping and genetic analyses;
and Aim 4 : perform data analysis and provide support for presentation and manuscript preparation. Centralization of data management and genomics services through the GSAC will provide uniform quality control of data across the BVMC and optimize communication and synergy between BVMC Projects. The GSAC is closely integrated with the BVMC Administrative Unit and the data management and gentics infrastructure and protocols have been implemented and refined during the first funding cycle of the BVMC and are in place for the proposed continuation of the program. A consistent high level of genetic and biostatistical input will be attained for all projects in the Program. This core structure will allow for optimal coordination of the clinical and basic science research program components by providing a single centralized resource and facilitating sharing of data and hypothesis generation across the Projects and other components of the BVMC.

Public Health Relevance

The Genetic and Statistical Analysis Core supports the Brain Vascular Malformation Consortium projects in study design, data management, statistical and genetic analysis, and manuscript preparation. This centralized resource aids in communication between projects, thus helping advance Consortium goals to improve understanding and clinical management of vascular malformations of the brain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54NS065705-06
Application #
8913454
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Moy, Claudia S
Project Start
Project End
Budget Start
2014-09-30
Budget End
2015-07-31
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Walcott, Brian P; Choudhri, Omar; Lawton, Michael T (2016) Brainstem cavernous malformations: Natural history versus surgical management. J Clin Neurosci 32:164-5
Choquet, Hélène; Trapani, Eliana; Goitre, Luca et al. (2016) Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radic Biol Med 92:100-9
Kavanaugh, Brian; Sreenivasan, Aditya; Bachur, Catherine et al. (2016) [Formula: see text]Intellectual and adaptive functioning in Sturge-Weber Syndrome. Child Neuropsychol 22:635-48
Merkel, Peter A; Manion, Michele; Gopal-Srivastava, Rashmi et al. (2016) The partnership of patient advocacy groups and clinical investigators in the rare diseases clinical research network. Orphanet J Rare Dis 11:66
Walcott, Brian P; Winkler, Ethan A; Rouleau, Guy A et al. (2016) Molecular, Cellular, and Genetic Determinants of Sporadic Brain Arteriovenous Malformations. Neurosurgery 63 Suppl 1:37-42
Kaplan, Emma H; Kossoff, Eric H; Bachur, Catherine D et al. (2016) Anticonvulsant Efficacy in Sturge-Weber Syndrome. Pediatr Neurol 58:31-6
Krings, T; Kim, H; Power, S et al. (2015) Neurovascular manifestations in hereditary hemorrhagic telangiectasia: imaging features and genotype-phenotype correlations. AJNR Am J Neuroradiol 36:863-70
Golden, Michael; Saeidi, Saba; Liem, Benny et al. (2015) Sensitivity of patients with familial cerebral cavernous malformations to therapeutic radiation. J Med Imaging Radiat Oncol 59:134-6
Choquet, H; Pawlikowska, L; Lawton, M T et al. (2015) Genetics of cerebral cavernous malformations: current status and future prospects. J Neurosurg Sci 59:211-20
Comi, Anne M (2015) Sturge-Weber syndrome. Handb Clin Neurol 132:157-68

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