Abstract

The Administrative Core for the Harvard Medical School/University of California Cyanide Countermeasure Discovery and Development will provide oversight and coordination for the scientific, fiscal, administrative, and regulatory aspects of the Center. The Center's overall goal is to act as a discovery and development pipeline for new countermeasures that will enhance our nation's medical response to cyanide in a range of threat scenarios. The core will facilitate implementation of the overall strategic plan, ensure that projects adhere to the metrics required to execute this plan, and offer the organizational and logistic support necessary to achieve the project goals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS079201-03
Application #
8730723
Study Section
Special Emphasis Panel (ZRG1-MDCN-J)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
$382,025
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Sips, Patrick Y; Shi, Xu; Musso, Gabriel et al. (2018) Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One 13:e0193889
Nath, Anjali K; Shi, Xu; Harrison, Devin L et al. (2017) Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol 24:565-575.e4
MacRae, Calum A; Boss, Gerry; Brenner, Matthew et al. (2016) A countermeasure development pipeline. Ann N Y Acad Sci 1378:58-67
MacRae, Calum A; Peterson, Randall T (2015) Zebrafish as tools for drug discovery. Nat Rev Drug Discov 14:721-31
Palchaudhuri, Rahul; Lambrecht, Michael J; Botham, Rachel C et al. (2015) A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Rep 13:2027-36
MacRae, Calum A (2015) A new phenotypic lexicon for accelerated translation: rise of the machines. Circulation 131:234-6
Burns, Andrew R; Luciani, Genna M; Musso, Gabriel et al. (2015) Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun 6:7485
Jackson, Randy; Oda, Robert P; Bhandari, Raj K et al. (2014) Development of a fluorescence-based sensor for rapid diagnosis of cyanide exposure. Anal Chem 86:1845-52
Musso, Gabriel; Tasan, Murat; Mosimann, Christian et al. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development 141:224-35
Lee, Jangwoen; Kim, Jae G; Mahon, Sari B et al. (2014) Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy. J Biomed Opt 19:055001

Showing the most recent 10 out of 16 publications