We propose to use data from the National Health and Nutrifion Examinafion Survey (NHANES) to describe racial differences over time in patterns of traditional stroke risk factors, novel biologic and social risk factors for stroke, and stroke risk scores. To better understand racial differences in the association between both traditional and non-traditional biological and social risk factors and the mechanisms underiying these relationships, we propose to address the following aims using data from NHANES:
Aim 1 : To describe trends in prevalence and control of tradifional stroke risk factors in NHANES III (1988- 1994) and NHANES 1999-2010 and how the trends differ among whites, African Americans, and Mexican Americans.
Aim 2 : To describe trends in non-traditional social risk factors for stroke (e.g. neighborhood characteristics) and novel biologic stroke risk factors (e.g. hsCRP, fibrinogen, and Lp(a)) in NHANES III and NHANES 1999-2010 and how the trends differ by race/ethnicity.
Aim 3 : To describe trends in 10-year stroke risk, 10-year CVD risk, and allostatic load, an index of cumulative biologic risk, using NHANES III and NHANES 1999-2010 and how the trends differ by race/ethnicity.
Aim 4 : Among stroke survivors in NHANES III and NHANES 1999-2004, to examine the associafion between mortality and novel biologic and social risk factors, after adjustment for traditional risk factors. We will also explore racial/ethnic differences in these associations. The use of NHANES data allows for detailed assessments of stroke risk factors and outcomes linked to extensive treatment, biomarker, geographic, and mortality data in a representative sample of U.S. adults.

Public Health Relevance

The proposed study will address gaps in our knowledge about racial/ethnic differences in trends in nontraditional biologic and social risk factors for stroke risk and outcomes. Enhanced understanding of these risk relationships is essential to any future efforts to develop more effective interventions to prevent strokes and reduce post-stroke morbidity and mortality.

National Institute of Health (NIH)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Hamid, Hamada; Blackmon, Karen; Cong, Xiangyu et al. (2014) Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. Neurology 82:887-94
Fogel, Brent L; Vickrey, Barbara G; Walton-Wetzel, Jenny et al. (2013) Utilization of genetic testing prior to subspecialist referral for cerebellar ataxia. Genet Test Mol Biomarkers 17:588-94
Berg, Anne T; Baca, Christine B; Loddenkemper, Tobias et al. (2013) Priorities in pediatric epilepsy research: improving children's futures today. Neurology 81:1166-75
Brown, Arleen F; Liang, Li-Jung; Vassar, Stefanie D et al. (2013) Neighborhood socioeconomic disadvantage and mortality after stroke. Neurology 80:520-7
Vickrey, Barbara G; Brott, Thomas G; Koroshetz, Walter J et al. (2013) Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report. Stroke 44:2338-42