The Los Angeles Stroke Prevention/ Intervention Research Program in Health Disparities is a partnership of UCLA, four medical centers in the Los Angeles County safety net system, Healthy African American Families, and representatives from multiple community organizations serving low-income minority communities that span the Los Angeles basin. In this most diverse county in the US in race/ethnicity, we propose a multi-disciplinary, highly collaborative Program to create and test sustainable interventions to reduce or eliminate racial and ethnic disparities in the occurrence of stroke, and to generate new knowledge about mechanisms for such disparities. Project I creates a strong community-based component with community health workers and mobile health technology to create a full-fledged Chronic Care Model intervention that will be tested relative to usual care in 500 patients with a recent stroke seen in the Los Angeles County safety net. A cost analysis and a formative evaluation will guide development of a financial sustainability plan. Project II will elucidate the role of novel biological and social risk factors for stroke risk and trends over time, in a nationa data set. Project III builds on an existing close partnership with the City of Los Angeles Department of Aging to develop and test a culturally-tailored behavioral stroke risk factor reduction/walking intervention - delivered by senior center staff-with 240 high risk seniors from Korean, Chinese, African-American and Hispanic racial/ethnic groups. Four cores include an Administrative Core A that supports all three projects;a Research Education and Training Core B that will recruit, retain, and develop stroke disparities-relevant curriculum for academic researchers, community research support personnel and other community stake holders;a Biomarker Collection and Analysis Core C to support Project I and III biomarker data collection, consulting for all three projects, and development of educational programming on biomarkers;and a Community Engagement, Outreach, and Dissemination Core D that supports and interacts with all three projects by promoting and sustaining community-academic partnerships through bidirectional knowledge sharing and by creating strategies for disseminating advances in knowledge about stroke prevention disparities research through outreach to affected communities locally and nationally.

Public Health Relevance

A coordinated effort of researchers and community partners is needed to reduce or eliminate the higher rates of stroke among low-income Latinos, African-Americans, and Asian Americans in underserved communities. The Los Angeles Stroke Prevention/Intervention Program in Health Disparities will carry out research, develop education programs, and share and learn from the community to meet this goal.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center--Cooperative Agreements (U54)
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Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Moy, Claudia S
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Choi, Sarah E; Kwon, Ivy; Chang, Emiley et al. (2016) Developing a culturally tailored stroke prevention walking programme for Korean immigrant seniors: a focus group study. Int J Older People Nurs 11:255-265
Bharmal, Nazleen; Lucas-Wright, Anna Aziza; Vassar, Stefanie D et al. (2016) A Community Engagement Symposium to Prevent and Improve Stroke Outcomes in Diverse Communities. Prog Community Health Partnersh 10:149-58
Kwon, Ivy; Bharmal, Nazleen; Choi, Sarah et al. (2016) Older Ethnic Minority Women's Perceptions of Stroke Prevention and Walking. Womens Health Issues 26:80-6
Mensah, George A; Sacco, Ralph L; Vickrey, Barbara G et al. (2015) From Data to Action: Neuroepidemiology Informs Implementation Research for Global Stroke Prevention and Treatment. Neuroepidemiology 45:221-9
Roumie, Christianne L; Zillich, Alan J; Bravata, Dawn M et al. (2015) Hypertension treatment intensification among stroke survivors with uncontrolled blood pressure. Stroke 46:465-70
Kwon, Ivy; Choi, Sarah; Mittman, Brian et al. (2015) Study protocol of ""Worth the Walk"": a randomized controlled trial of a stroke risk reduction walking intervention among racial/ethnic minority older adults with hypertension in community senior centers. BMC Neurol 15:91
Lin, Michelle P; Ovbiagele, Bruce; Markovic, Daniela et al. (2015) ""Life's Simple 7"" and Long-Term Mortality After Stroke. J Am Heart Assoc 4:
Moura, Lidia M V R; Mendez, Diego Yacaman; Jesus, Jonathan De et al. (2015) Association of adherence to epilepsy quality standards with seizure control. Epilepsy Res 117:35-41
Vickrey, Barbara G (2015) Comment: The changing practice of neurology and a look to the future. Neurology 84:2090
Hamid, Hamada; Blackmon, Karen; Cong, Xiangyu et al. (2014) Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. Neurology 82:887-94

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