This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The RMATRIX Participant and Clinical Resources (PCR) Key Function is a centralized research infrastructure designed to facilitate and support clinical and translational research in Hawaii. The PCR consolidates three CRC clinical sites, including Kapiolani Medical Center for Women and Children, The Queen's Medical Center, and the Hawaii Center for AIDS, a biospecimen repository, and community clinics spanning the island of Oahu. PCR resources are essential to the innovative research focused in the RMATRIX HEALTH initiatives and provides an array of services for researchers dedicated to improving the health and well-being of Hawaii's people. The PCR includes the Research Coordinator Corps consisting of research nurses, clinical coordinators, study coordinators and research assistants, and provides facilities and state-of-the-art equipment to support meaningful clinical and translation research addressing issues of concern for our island community. The PCR prides itself in providing an array of highly specialized, customizable services and experienced research staff dedicated to assist research teams in implementing their protocols. Services include participation in protocol development activities, feasibility consults to assure appropriate enrollment target, level of staffing, skill and expertise of personnel, resource availability and adequate funding, project management support, proficient recruitment and enrollment strategies, data collection, data input and database management, secure maintenance and transfer of data and records, consistency in specimen processing and proactive regulatory and compliance monitoring throughout the study period. PCR staff exemplifies sound judgment and principles of Good Clinical Practice and Responsible Conduct of Research, prioritizing the ethical conduct of research and participant safety throughout their practice.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR026136-02
Application #
8364966
Study Section
Special Emphasis Panel (ZRR1-RI-1 (02))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
2
Fiscal Year
2011
Total Cost
$1,687,394
Indirect Cost
Name
University of Hawaii
Department
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
McIntosh, Roger C; Chow, Dominic C; Lum, Corey J et al. (2017) Reduced functional connectivity between ventromedial prefrontal cortex and insula relates to longer corrected QT interval in HIV+ and HIV- individuals. Clin Neurophysiol 128:1839-1850
Chuang, Eleanore; Lim, Eunjung; Milne, Cris et al. (2016) Human Papillomavirus at Multiple Sites Associated with Anal Squamous Intraepithelial Lesions in HIV-Seropositive Individuals. Ann Clin Cytol Pathol 2:
Kallianpur, Kalpana J; Gerschenson, Mariana; Mitchell, Brooks I et al. (2016) Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients. Mitochondrion 28:8-15
Chow, Dominic; Kohorn, Lindsay; Souza, Scott et al. (2016) Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin. AIDS 30:672-4
Eze, Nwando; Smith, Lynne M; LaGasse, Linda L et al. (2016) School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study. J Pediatr 170:34-8.e1
Gangcuangco, Louie Mar A; Kohorn, Lindsay B; Chow, Dominic C et al. (2016) High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy. Medicine (Baltimore) 95:e5270
Munger, Alana M; Chow, Dominic C; Playford, Martin P et al. (2015) Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens. AIDS Res Hum Retroviruses 31:221-8
Chow, Dominic; Young, Rebekah; Valcour, Nicole et al. (2015) HIV and coronary artery calcium score: comparison of the Hawaii Aging with HIV Cardiovascular Study and Multi-Ethnic Study of Atherosclerosis (MESA) cohorts. HIV Clin Trials 16:130-8
Parikh, Nisha I; Gerschenson, Mariana; Bennett, Kara et al. (2015) Lipoprotein concentration, particle number, size and cholesterol efflux capacity are associated with mitochondrial oxidative stress and function in an HIV positive cohort. Atherosclerosis 239:50-4
Shikuma, Cecilia M; Bennett, Kara; Ananworanich, Jintanat et al. (2015) Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy. J Neurovirol 21:525-34

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