This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
The specific aims for our study have not been modified at this time. Our long-term objective is still to identify and eliminate factors that contribute to racial/ethnic disparities in mental health treatment. Toward that goal, the proposed study is designed to identify the main predictors of mental health and medical treatment linkage and engagement in an African American population with severe and persistent mental illness. The central hypothesis of this proposal is that specific attitudinal, clinical, and social factors are highly correlated with linkage and engagement with mental health and medical treatment. By identifying these factors, our goal is to design targeted interventions to improve negative factors and enhance positive factors that contribute to overall linkage and engagement in mental health and medical treatment in racial/ethnic minority populations. Regarding each specific aim, we are beginning to make progress toward each of these goals.
Specific Aim 1 : To determine the predictors of mental health treatment linkage and engagement among low-income, socially disadvantaged, predominantly African American individuals with severe mental illness.
Specific Aim 2 : To determine the predictors of general medical services treatment linkage among low-income, socially disadvantaged, predominantly African American individuals with severe mental illness.
Specific Aim 3 : To determine the association between successful linkage with mental health services and general medical services. We anticipate an analysis of individuals with severe mental illness and their rates of ongoing linkage and engagement in mental health and medical treatment will help to improve overall treatment of individuals with severe mental illness. Because we are focusing this study on a predominantly African American population, we hope to gain greater understanding that will serve to eliminate racial/ethnic disparities associated with mental health and medical treatment.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Morehouse School of Medicine
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Gianesini, Coralie; Hiragaki, Susumu; Laurent, Virginie et al. (2016) Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. Invest Ophthalmol Vis Sci 57:94-104
Simmons, Lauren J; Surles-Zeigler, Monique C; Li, Yonggang et al. (2016) Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. J Neuroinflammation 13:237
White, Todd E; Surles-Zeigler, Monique C; Ford, Gregory D et al. (2016) Bilateral gene interaction hierarchy analysis of the cell death gene response emphasizes the significance of cell cycle genes following unilateral traumatic brain injury. BMC Genomics 17:130
Jockers, Ralf; Delagrange, Philippe; Dubocovich, Margarita L et al. (2016) Update on melatonin receptors: IUPHAR Review 20. Br J Pharmacol 173:2702-25
Hyacinth, Hyacinth I; Adams, Robert J; Greenberg, Charles S et al. (2015) Effect of Chronic Blood Transfusion on Biomarkers of Coagulation Activation and Thrombin Generation in Sickle Cell Patients at Risk for Stroke. PLoS One 10:e0134193
Rust, George; Zhang, Shun; Holloway, Kelvin et al. (2015) Timing of emergency department visits for childhood asthma after initial inhaled corticosteroid use. Popul Health Manag 18:54-60
Zhang, Yuanyuan; George, Jasmine; Li, Yun et al. (2015) Matrix metalloproteinase-9 expression is enhanced in renal parietal epithelial cells of zucker diabetic Fatty rats and is induced by albumin in in vitro primary parietal cell culture. PLoS One 10:e0123276
Li, Yonggang; Lein, Pamela J; Ford, Gregory D et al. (2015) Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. J Neuroinflammation 12:64
Hyacinth, Hyacinth I; Adams, Robert J; Voeks, Jenifer H et al. (2014) Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk. Am J Hematol 89:47-51
Hiragaki, Susumu; Baba, Kenkichi; Coulson, Elise et al. (2014) Melatonin signaling modulates clock genes expression in the mouse retina. PLoS One 9:e106819

Showing the most recent 10 out of 60 publications