This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiovascular disease (CVD) and related disorders remain the leading cause of death in the nation and diabetes in strongly linked to CVD. African-Americans, Hispanic/Latino Americans, American Indians, Alaska Natives, some Asian-Americans, Native Hawaiians and other Pacific Islanders, are at particularly high risk for the development o type 2 diabetes. Rates of diabetes in ethnic and racial minorities are presently increased (1) and are projected to continue to increase at an alarming rate (2). Although access to medical care or genetic variations may have a role, an intriguing biological explanation to help explain this health disparity is racial differences in vitamin Dlevels. Racial/ethnic minorities have reduced serum 25-hydroxy vitamin D 925-OHD) levels, with African-Americans having lower levels than Caucasians and Hispanic/Latino Americans having intermediate levels (3-5). The low serum 25-OHD levels in racial/ethnic minorities may be due to increased skin pigmentation, although reduced sun exposure, reduced dietary intake of vitamin D or other factor may also play a role.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZRR1-RI-8 (01))
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Charles R. Drew University of Medicine & Science
Other Domestic Higher Education
Los Angeles
United States
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Ghoneum, Mamdooh; Felo, Nouran (2015) Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep 34:1659-66
Ghoneum, Mamdooh H; Badr El-Din, Nariman K; Abdel Fattah, Salma M et al. (2015) Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci 11:295-303
Sinha-Hikim, I; Duran, P; Shen, R et al. (2015) Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res 47:280-3
Kahn, Richard; Davidson, Mayer B (2014) The reality of type 2 diabetes prevention. Diabetes Care 37:943-9
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Davidson, Mayer B; Pan, Deyu (2014) Epidemiological ramifications of diagnosing diabetes with HbA1c levels. J Diabetes Complications 28:464-9
Ivey, R; Desai, M; Green, K et al. (2014) Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res 46:568-73
Davidson, Mayer B (2014) Insulin analogs--is there a compelling case to use them? No! Diabetes Care 37:1771-4
Davidson, Mayer B; Duran, Petra; Lee, Martin L (2014) Community screening for pre-diabetes and diabetes using HbA1c levels in high-risk African Americans and Latinos. Ethn Dis 24:195-9
Mahboubi, Hossein; Zardouz, Shawn; Oliaei, Sepehr et al. (2013) Noise-induced hearing threshold shift among US adults and implications for noise-induced hearing loss: National Health and Nutrition Examination Surveys. Eur Arch Otorhinolaryngol 270:461-7

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