The University of Iowa (Ul) Institute for Clinical and Translational Science (ICTS) is ideally positioned to accomplish the ultimate goal of the CTSA initiative - to promote the true translation of research from bench to bedside, to community, to individual patient, and back. Since its creation, the ICTS has successfully engaged investigators, trainees, and research staff from all 11 Ul colleges -- Medicine, Public Health, Dentistry, Nursing, Pharmacy, Engineering, Liberal Arts and Sciences, Education, Law, Business, and Graduate. The ICTS also crafted collaborations with Iowa State University, the VA Midwest Health Care Network, the Iowa Primary Care Association, and clinical networks that care for rural and other underserved populations and that support T2 - T4 translational studies. This application will further enhance our infrastructures, facilitate more sophisticated translational research, position the ICTS to assume an even greater institutional role in improving regulatory procedures, and increase access of our collaborating organizations to clinical research support and data warehousing and access of other CTSA institutions to our unique resources. The four aims related to these efforts are to: 1) Catalyze innovative T1 - T4 Science through: new pilot programs to support interdisciplinary high impact research;facilitation of new collaborations between bench, clinical, and population-based scientists;enhancement of the environment for team science;and a new program in drug discovery and development. 2) Improve research efficiency through: novel approaches to increase subject recruitment and decrease data collection costs;adoption of shared IRB arrangements and master contracts;supporting NIH multi-site research networks;and tightly linking program evaluation data to decisions about resource allocation. 3) Create and nurture partnerships with: Ul research centers to leverage resources and avoid duplication of services;regional healthcare providers to expand opportunities for T2 - T4 research;other CTSA institutions to disseminate novel Ul products and import promising scientific and administrative approaches;and private biotechnology firms. 4) Build dynamic educational, service, and informatics infrastructures to: support the training needs of translational investigators across the career spectrum;support the research services needs of T1 - T4 investigators;and enable highly productive, safe and secure research.

Public Health Relevance

This application will help support the work of the University of Iowa Institute for Clinical and Translational Science to provide infrastructures to improve both the quality and efficiency of translational research

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54TR001013-01
Application #
8604041
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Davis Nagel, Joan
Project Start
2014-09-01
Project End
2015-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Organized Research Units
DUNS #
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Curtis, Alexandra M; VanBuren, John; Cavanaugh, Joseph E et al. (2018) Longitudinal associations between dental caries increment and risk factors in late childhood and adolescence. J Public Health Dent 78:321-328
Hannan, Anthony J (2018) Tandem Repeats and Repeatomes: Delving Deeper into the 'Dark Matter' of Genomes. EBioMedicine 31:3-4
Merriwether, Ericka N; Frey-Law, Laura A; Rakel, Barbara A et al. (2018) Physical activity is related to function and fatigue but not pain in women with fibromyalgia: baseline analyses from the Fibromyalgia Activity Study with TENS (FAST). Arthritis Res Ther 20:199
Dindo, Lilian; Zimmerman, M Bridget; Hadlandsmyth, Katherine et al. (2018) Acceptance and Commitment Therapy for Prevention of Chronic Postsurgical Pain and Opioid Use in At-Risk Veterans: A Pilot Randomized Controlled Study. J Pain 19:1211-1221
Johnson, Casey P; Christensen, Gary E; Fiedorowicz, Jess G et al. (2018) Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1? mapping. Bipolar Disord 20:381-390
Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264
Monga, Varun; Maliske, Seth M; Kaleem, Hassan et al. (2018) Discrepancy between treatment goals documentation by oncologists and their understanding among cancer patients under active treatment with chemotherapy. Eur J Cancer Care (Engl) :e12973
Shaffer Jr, Joseph J; Johnson, Casey P; Fiedorowicz, Jess G et al. (2018) Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states. Brain Imaging Behav 12:837-847
Lee, Jessica K; Ding, Yue; Conrad, Amy L et al. (2017) Sex-specific effects of the Huntington gene on normal neurodevelopment. J Neurosci Res 95:398-408
Warren, John J; Van Buren, John M; Levy, Steven M et al. (2017) Dental caries clusters among adolescents. Community Dent Oral Epidemiol 45:538-544

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