The Environmental Determinants of Diabetes in the Young (TEDDY) study was initiated in 2003 by six clinical centers in the United States and Europe, including ours, to identify infectious agents, dietary factors, or other environmental exposures that may trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). Additional long-term scientific goals include assessment of potential gene-environment interactions affecting development of islet autoimmunity or T1D, gaining insight on mechanisms, and sharing collected specimens with broader scientific community for studies of T1D pathogenesis and prevention. A total of 424,788 newborns have been screened by HLA-DR, DQ genotyping to identify children at increased risk for T1D and 8677 are followed four times a year until 4 years of age and twice a year thereafter until age 15. Our Clinical Center has enrolled 1834 TEDDY participants;of those 114 have developed persistent confirmed islet autoantibodies and 36 have been diagnosed with T1D, as of 6/30/2012.

Public Health Relevance

The Environmental Determinants of Diabetes in the Young (TEDDY) Study is designed to intensively study children from infancy to 15 years of age, at six clinical centers across four countries (Finland, Sweden, Germany, and the USA in Georgia/Florida, Colorado, and Washington). Infants screened at birth and identified as genetically (HLA) eligible were offered enrollment in the follow-up study, regardless of gender or ethnicity. The primary objective of this multi-center, prospective cohort study initiated in 2003 i the identification of infections agents, dietary factors, or other environmental exposures that trigger or protect against the development of islet autoimmunity and type 1diabetes (T1D).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
High Impact Research and Research Infrastructure Cooperative Agreement Programs—Multi-Yr Funding (UC4)
Project #
2UC4DK063863-11
Application #
8536980
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J2))
Program Officer
Spain, Lisa M
Project Start
2003-04-01
Project End
2018-05-31
Budget Start
2013-06-05
Budget End
2018-05-31
Support Year
11
Fiscal Year
2013
Total Cost
$5,562,000
Indirect Cost
$412,000
Name
Hospital District of Southwest Finland
Department
Type
DUNS #
368919671
City
Turku
State
Country
Finland
Zip Code
FI-20-521
Elding Larsson, Helena; Vehik, Kendra; Haller, Michael J et al. (2016) Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study. Diabetes 65:1988-95
Lernmark, Barbro; Lynch, Kristian; Baxter, Judith et al. (2016) Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing. J Diabetes Res 2016:2720650
Uusitalo, Ulla; Liu, Xiang; Yang, Jimin et al. (2016) Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA Pediatr 170:20-8
Sharma, Ashok; Liu, Xiang; Hadley, David et al. (2016) Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLoS One 11:e0152476
Yang, Jimin; Lynch, Kristian F; Uusitalo, Ulla M et al. (2016) Factors associated with longitudinal food record compliance in a paediatric cohort study. Public Health Nutr 19:804-13
Törn, Carina; Liu, Xiang; Hagopian, William et al. (2016) Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. Sci Rep 6:27887
Johnson, Suzanne Bennett; Lynch, Kristian F; Baxter, Judith et al. (2016) Predicting Later Study Withdrawal in Participants Active in a Longitudinal Birth Cohort Study for 1 Year: The TEDDY Study. J Pediatr Psychol 41:373-83
Andrén Aronsson, Carin; Lee, Hye-Seung; Koletzko, Sibylle et al. (2016) Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol 14:403-409.e3
Haghighi, Mona; Johnson, Suzanne Bennett; Qian, Xiaoning et al. (2016) A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Sci Rep 6:30828
Swartling, Ulrica; Lynch, Kristian; Smith, Laura et al. (2016) Parental Estimation of Their Child's Increased Type 1 Diabetes Risk During the First 2 Years of Participation in an International Observational Study: Results From the TEDDY study. J Empir Res Hum Res Ethics 11:106-14

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