The Environmental Determinants of Diabetes in the Young (TEDDY) study was initiated in 2003 by six clinical centers in the United States and Europe, including ours, to identify infectious agents, dietary factors, or other environmental exposures that may trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). Additional long-term scientific goals include assessment of potential gene-environment interactions affecting development of islet autoimmunity or T1D, gaining insight on mechanisms, and sharing collected specimens with broader scientific community for studies of T1D pathogenesis and prevention. A total of 424,788 newborns have been screened by HLA-DR, DQ genotyping to identify children at increased risk for T1D and 8677 are followed four times a year until 4 years of age and twice a year thereafter until age 15. Our Clinical Center has enrolled 1834 TEDDY participants;of those 114 have developed persistent confirmed islet autoantibodies and 36 have been diagnosed with T1D, as of 6/30/2012.

Public Health Relevance

The Environmental Determinants of Diabetes in the Young (TEDDY) Study is designed to intensively study children from infancy to 15 years of age, at six clinical centers across four countries (Finland, Sweden, Germany, and the USA in Georgia/Florida, Colorado, and Washington). Infants screened at birth and identified as genetically (HLA) eligible were offered enrollment in the follow-up study, regardless of gender or ethnicity. The primary objective of this multi-center, prospective cohort study initiated in 2003 i the identification of infections agents, dietary factors, or other environmental exposures that trigger or protect against the development of islet autoimmunity and type 1diabetes (T1D).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
High Impact Research and Research Infrastructure Cooperative Agreement Programs—Multi-Yr Funding (UC4)
Project #
2UC4DK063863-11
Application #
8536980
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J2))
Program Officer
Spain, Lisa M
Project Start
2003-04-01
Project End
2018-05-31
Budget Start
2013-06-05
Budget End
2018-05-31
Support Year
11
Fiscal Year
2013
Total Cost
$5,562,000
Indirect Cost
$412,000
Name
Hospital District of Southwest Finland
Department
Type
DUNS #
368919671
City
Turku
State
Country
Finland
Zip Code
FI-20-521
Elding Larsson, Helena; Vehik, Kendra; Gesualdo, Patricia et al. (2014) Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr Diabetes 15:118-26
Liu, Edwin; Lee, Hye-Seung; Aronsson, Carin A et al. (2014) Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med 371:42-9
Yang, J; Lernmark, Å; Uusitalo, U M et al. (2014) Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. Int J Obes (Lond) 38:1491-6
Johnson, Suzanne Bennett; Lynch, Kristian F; Lee, Hye-Seung et al. (2014) At high risk for early withdrawal: using a cumulative risk model to increase retention in the first year of the TEDDY study. J Clin Epidemiol 67:609-11
Smith, Laura B; Lynch, Kristian F; Baxter, Judith et al. (2014) Factors associated with maternal-reported actions to prevent type 1 diabetes in the first year of the TEDDY study. Diabetes Care 37:325-31
Hummel, Sandra; Vehik, Kendra; Uusitalo, Ulla et al. (2014) Infant feeding patterns in families with a diabetes history - observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study. Public Health Nutr 17:2853-62