The Alliance NCI Community Oncology Research Program (NCORP) Research Base conducts interventional and observational clinical trials as well as database analyses addressing important questions concerning cancer prevention, screening, symptom intervention, post-treatment surveillance/survivorship, quality of life and cancer care delivery. We place special emphasis upon issues affecting minority, underserved and elderly patient groups, and upon building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance for Clinical Trials in Oncology (Alliance), one of the five National Clinical Trials Network (NCTN) groups, serves as the coordinating center for the conduct of all NCORP Research Base trials. The Alliance members represent community practices and academic medical centers in approximately equal number, so the results of the trials broadly reflect the actual experience of patients across the United States. In order to improve our understanding of the biological basis of cancer risk and pre-malignant disease, biomarkers that detect pre-symptomatic newly diagnosed or recurrent malignancies, as well as the physiologic mechanisms of cancer-related symptoms and treatment-related toxicities, most of our clinical trials include translational research questions requiring the collection of tumor tissue, premalignant tissue samples, blood, or other human biospecimens. These biospecimens create an invaluable repository for understanding the associations between laboratory and clinical observations. The Alliance NCORP Research Base collaborates broadly with other NCORP Research Bases to enroll patients in trials, conduct translational studies, and share data and biospecimens for pooled analyses. We also collaborate broadly with other NCI-funded investigators and consortia, as well as investigators supported through non-NCI sources. Results of Alliance investigator efforts have resulted in more than 99 abstracts and manuscripts over the past five years, many resulting in significant beneficial changes in clinical practice. The scientific questions answered by the Alliance NCORP Research Base represent meaningful and innovative contributions to biomedical sciences, and can only be addressed through a publicly-funded research network.

Public Health Relevance

Approximately one in three women and one in two men in the United States will be diagnosed with cancer during their lifetime. Research to prevent cancer, detect cancer while it is still curable, improve symptoms related to cancer and its treatment, and enhance cancer care delivery strategies will provide major health and economic benefits for Americans and people around the world.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Clinical Research Cooperative Agreements - Single Project (UG1)
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Special Emphasis Panel (ZCA1-GRB-I (M1))
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Mccaskill-Stevens, Worta J
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Mayo Clinic, Rochester
United States
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Ji, YongLi; Rounds, Tiffany; Crocker, Abigail et al. (2016) The Effect of Atorvastatin on Breast Cancer Biomarkers in High-Risk Women. Cancer Prev Res (Phila) 9:379-84
Warner, Erica T; Ballman, Karla V; Strand, Carrie et al. (2016) Impact of race, ethnicity, and BMI on achievement of pathologic complete response following neoadjuvant chemotherapy for breast cancer: a pooled analysis of four prospective Alliance clinical trials (A151426). Breast Cancer Res Treat 159:109-18
Kilari, Deepak; Soto-Perez-de-Celis, Enrique; Mohile, Supriya Gupta et al. (2016) Designing exercise clinical trials for older adults with cancer: Recommendations from 2015 Cancer and Aging Research Group NCI U13 Meeting. J Geriatr Oncol 7:293-304
Sio, Terence T; Atherton, Pamela J; Birckhead, Brandon J et al. (2016) Repeated measures analyses of dermatitis symptom evolution in breast cancer patients receiving radiotherapy in a phase 3 randomized trial of mometasone furoate vs placebo (N06C4 [alliance]). Support Care Cancer 24:3847-55
Bennett, Antonia V; Keenoy, Kathleen; Shouery, Marwan et al. (2016) Evaluation of mode equivalence of the MSKCC Bowel Function Instrument, LASA Quality of Life, and Subjective Significance Questionnaire items administered by Web, interactive voice response system (IVRS), and paper. Qual Life Res 25:1123-30
Loh, Kah Poh; Janelsins, Michelle C; Mohile, Supriya G et al. (2016) Chemotherapy-related cognitive impairment in older patients with cancer. J Geriatr Oncol 7:270-80
Karuturi, Meghan; Wong, Melisa L; Hsu, Tina et al. (2016) Understanding cognition in older patients with cancer. J Geriatr Oncol 7:258-69
Flannery, Marie; Mohile, Supriya Gupta; Dale, William et al. (2016) Interventions to improve the quality of life and survivorship of older adults with cancer: The funding landscape at NIH, ACS and PCORI. J Geriatr Oncol 7:225-33
Freedman, Rachel A; Seisler, D K; Foster, J C et al. (2016) Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511). Breast Cancer Res Treat :
Magnuson, Allison; Allore, Heather; Cohen, Harvey Jay et al. (2016) Geriatric assessment with management in cancer care: Current evidence and potential mechanisms for future research. J Geriatr Oncol 7:242-8

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