: The Wake Forest NCORP Cancer Center Research Base will continue to utilize the unique resources and expertise of the established and productive Wake Forest Cancer Center CCOP Research Base and build on established collaborations with our NCORP community partners, consultants and other Research Bases to address cancer and treatment-related symptoms and toxicities, cancer care delivery issues, and cancer related health disparities as outlined below.
Specific Aim 1 : To expand our cancer control clinical trial activities in the following areas: 1) Cardiovascular complications of cancer therapy including early diagnosis, intervention and prevention strategies; 2) Neurocognitive complications of cancer therapy with an emphasis on prevention and early treatment of radiation and chemotherapy-induced neuro-cognitive effects, as well as identification and treatment of patients with established toxicity; and 3) Additional cancer and treatment-related symptoms and toxicities experienced across the spectrum from diagnosis through long-term survivorship.
Specific Aim 2 : To grow and strengthen our CCDR portfolio in conjunction with NCORP community sites and collaboration with other NCORP research bases. We will emphasize studies that complement our established thematic areas of expertise in cardiovascular complications and survivorship.
Specific Aim 3 : To elucidate the basic mechanisms underlying cancer and treatment-related symptoms and toxicities through bio specimen collection and correlative science accompanying our clinical investigations. These efforts will facilitate a better understanding of treatment outcomes and efficacy, and identification of individuals for whom specific interventions will or wil not be effective.
Specific Aim 4 : To maintain and build on our success in recruiting racial and ethnic minority and underserved populations across all research investigations pursued by the Wake Forest NCORP Cancer Center Research Base.
Specific Aim 5 : To train the next generation of medical and public health researchers through involvement and mentoring of early career faculty, medical oncology and radiation oncology trainees, and public health post-doctoral fellows and students in Wake Forest NCORP Research Base activities.

Public Health Relevance

Our overarching goal is to improve the quality of life and quality of care experienced by patients with cancer by developing and completing cutting edge cancer control and cancer care delivery clinical trials through the Wake Forest NCORP Cancer Center Research Base.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1CA189824-03
Application #
9117485
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Russo, Sandra
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
3
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Cathcart-Rake, Elizabeth J; Zemla, Tyler; Jatoi, Aminah et al. (2018) Acquisition of sexual orientation and gender identity data among NCI Community Oncology Research Program practice groups. Cancer :
Lamar, Zanetta S; Dothard, Andrew; Kennedy, LeAnne et al. (2018) Hyperglycemia during first-line R-CHOP or dose adjusted R-EPOCH chemotherapy for non-Hodgkin lymphoma is prevalent and associated with chemotherapy alteration - a retrospective study. Leuk Lymphoma 59:1871-1877
Datta, Mridul; Shaw, Edward G; Lesser, Glenn J et al. (2018) A Randomized Double-Blind Placebo-Controlled Trial of Fruit and Vegetable Concentrates on Intermediate Biomarkers in Head and Neck Cancer. Integr Cancer Ther 17:115-123
Carlos, Ruth C; Sicks, JoRean D; Chang, George J et al. (2017) Capacity for Cancer Care Delivery Research in National Cancer Institute Community Oncology Research Program Community Practices: Availability of Radiology and Primary Care Research Partners. J Am Coll Radiol 14:1530-1537
Okoukoni, Catherine; McTyre, Emory R; Ayala Peacock, Diandra N et al. (2017) Hippocampal dose volume histogram predicts Hopkins Verbal Learning Test scores after brain irradiation. Adv Radiat Oncol 2:624-629
Gifford, Abigail R; Lawrence, Julia A; Baker, Laura D et al. (2017) National Institute on Aging /Alzheimer's Association criteria for Mild Cognitive Impairment applied to chemotherapy treated breast cancer survivors. J Oncol Research 1:
Jordan, Jennifer H; Vasu, Sujethra; Morgan, Timothy M et al. (2016) Anthracycline-Associated T1 Mapping Characteristics Are Elevated Independent of the Presence of Cardiovascular Comorbidities in Cancer Survivors. Circ Cardiovasc Imaging 9:
Lawrence, J A; Griffin, L; Balcueva, E P et al. (2016) A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy. J Cancer Surviv 10:176-84
Danhauer, Suzanne C; Griffin, Leah P; Avis, Nancy E et al. (2015) Feasibility of implementing a community-based randomized trial of yoga for women undergoing chemotherapy for breast cancer. J Community Support Oncol 13:139-147
Greven, Kathryn M; Case, L Douglas; Nycum, Lawrence R et al. (2015) Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106. J Community Support Oncol 13:87-94

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