ECOG-ACRIN (E-A) represents the merger of ECOG and ACRIN to form a cooperative group focused on practice-changing clinical and translational research across the cancer care continuum from prevention and early detection, through the management of advanced disease and its impact. This NCORP Research Base application represents an ambitious program that continues the E-A legacy of community based, high impact research in cancer prevention and early detection, and in embedding patient-centered outcomes into therapeutic trials, and extends our traditional research base activities to include an expanded emphasis on studying disparities, the unique needs of older and younger adults diagnosed with cancer, and cancer care delivery research. There is particular emphasis on the relationship between early detection and therapy of early disease in an effort to reduce morbidity of overtreatment. There is also an emphasis on studying the biology that drives symptoms and toxicity with a particular focus on cardiotoxicity and taxane related neuropathy. Key collaborations with community-based oncology programs will ensure access to E-A NCORP trials in communities where patients receive their care. Leveraging existing NCI-funded resources as well as a network of >10000 physicians, scientists, nurses, research associates (RAs), statisticians, biomedical information technologists, and patient advocates across approximately 600 institutions and organizations, E-A is poised to make significant contributions as a member of the NCORP community.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-I (M1))
Program Officer
Xie, Heng
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Ecog-Acrin Medical Research Foundation
United States
Zip Code
Tevaarwerk, Amye J; Lee, Ju-Whei; Terhaar, Abigail et al. (2016) Working after a metastatic cancer diagnosis: Factors affecting employment in the metastatic setting from ECOG-ACRIN's Symptom Outcomes and Practice Patterns study. Cancer 122:438-46
Cohee, Andrea A; Stump, Timothy; Adams, Rebecca N et al. (2016) Factors associated with depressive symptoms in young long-term breast cancer survivors. Qual Life Res 25:1991-7
Adams, Rebecca N; Mosher, Catherine E; Cohee, Andrea A et al. (2016) Avoidant coping and self-efficacy mediate relationships between perceived social constraints and symptoms among long-term breast cancer survivors. Psychooncology :
Weldon, Christine B; Friedewald, Sarah M; Kulkarni, Swati A et al. (2016) Radiology as the Point of Cancer Patient and Care Team Engagement: Applying the 4R Model at a Patient's Breast Cancer Care Initiation. J Am Coll Radiol 13:1579-1589
Gesselman, Amanda N; Bigatti, Silvia M; Garcia, Justin R et al. (2016) Spirituality, emotional distress, and post-traumatic growth in breast cancer survivors and their partners: an actor-partner interdependence modeling approach. Psychooncology :
Lewis, Mark A; Zhao, Fengmin; Jones, Desiree et al. (2015) Neuropathic Symptoms and Their Risk Factors in Medical Oncology Outpatients With Colorectal vs. Breast, Lung, or Prostate Cancer: Results From a Prospective Multicenter Study. J Pain Symptom Manage 49:1016-24
Fisch, Michael J; Zhao, Fengmin; Manola, Judith et al. (2015) Patterns and predictors of antidepressant use in ambulatory cancer patients with common solid tumors. Psychooncology 24:523-32
Newitt, David C; Tan, Ek T; Wilmes, Lisa J et al. (2015) Gradient nonlinearity correction to improve apparent diffusion coefficient accuracy and standardization in the american college of radiology imaging network 6698 breast cancer trial. J Magn Reson Imaging 42:908-19
Maldonado, Fabien; Duan, Fenghai; Raghunath, Sushravya M et al. (2015) Noninvasive Computed Tomography-based Risk Stratification of Lung Adenocarcinomas in the National Lung Screening Trial. Am J Respir Crit Care Med 192:737-44
Jones, Desiree; Zhao, Fengmin; Brell, Joanna et al. (2015) Neuropathic symptoms, quality of life, and clinician perception of patient care in medical oncology outpatients with colorectal, breast, lung, and prostate cancer. J Cancer Surviv 9:1-10

Showing the most recent 10 out of 27 publications