ECOG-ACRIN (E-A) represents the merger of ECOG and ACRIN to form a cooperative group focused on practice-changing clinical and translational research across the cancer care continuum from prevention and early detection, through the management of advanced disease and its impact. This NCORP Research Base application represents an ambitious program that continues the E-A legacy of community based, high impact research in cancer prevention and early detection, and in embedding patient-centered outcomes into therapeutic trials, and extends our traditional research base activities to include an expanded emphasis on studying disparities, the unique needs of older and younger adults diagnosed with cancer, and cancer care delivery research. There is particular emphasis on the relationship between early detection and therapy of early disease in an effort to reduce morbidity of overtreatment. There is also an emphasis on studying the biology that drives symptoms and toxicity with a particular focus on cardiotoxicity and taxane related neuropathy. Key collaborations with community-based oncology programs will ensure access to E-A NCORP trials in communities where patients receive their care. Leveraging existing NCI-funded resources as well as a network of >10000 physicians, scientists, nurses, research associates (RAs), statisticians, biomedical information technologists, and patient advocates across approximately 600 institutions and organizations, E-A is poised to make significant contributions as a member of the NCORP community.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1CA189828-04
Application #
9324165
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Pearson, Deborah
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Ecog-Acrin Medical Research Foundation
Department
Type
DUNS #
078579855
City
Philadelphia
State
PA
Country
United States
Zip Code
19103
Charkhchi, Paniz; Fazeli Dehkordy, Soudabeh; Carlos, Ruth C (2018) Housing and Food Insecurity, Care Access, and Health Status Among the Chronically Ill: An Analysis of the Behavioral Risk Factor Surveillance System. J Gen Intern Med 33:644-650
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Zhao, Fengmin; Cella, David; Manola, Judith et al. (2018) Fatigue among patients with renal cell carcinoma receiving adjuvant sunitinib or sorafenib: patient-reported outcomes of ECOG-ACRIN E2805 trial. Support Care Cancer 26:1889-1895
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Estabrook, Ryne; Cella, David; Zhao, Fengmin et al. (2018) Longitudinal and dynamic measurement invariance of the FACIT-Fatigue scale: an application of the measurement model of derivatives to ECOG-ACRIN study E2805. Qual Life Res 27:1589-1597
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Li, Megan; Mulkey, Flora; Jiang, Chen et al. (2018) Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance). Clin Cancer Res 24:4734-4744

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