The Cancer Research Consortium of West Michigan (CRCWM), formed by two experienced Clinical Community Oncology Programs (CCOPs), a NCI Community Cancer Centers Program, one medical school and a basic science institute is ideally positioned to fulfill the role of a NCORP. CRCWM has a committed group of eleven health systems, 90+ knowledgeable investigators and a well-established administrative structure. CRCWM is a large accrue to NCI clinical trials and is able to enroll minorities, underserved and rural individuals. As demonstrated in this application, CRCWM is experienced in Cancer Care Delivery Research (CCDR) and committed to further development of resources to make additional contributions to this NCI initiative.
The specific aims of the CRCWM are: 1. To maximize the accrual of patients to cancer clinical trials sponsored by the National Cancer Institute. 2. To become strong contributors to Cancer Care Delivery Research (CCDR). 3. To address health care disparities by expanding accrual of underserved and minority populations through enhanced relationships with community partners. 4. To maximize the adoption of NCI scientific findings into clinical care through education and engagement of clinical partners and health systems. 5. To expand our network and health system partnerships (rural and urban, large and small) in order to bring NCI clinical trials and education to targeted populations. 6. T develop and mentor young investigators and expand our leadership roles in the emerging National Clinical Trials Network (NCTN) in order to optimize our contribution to the national scientific agenda.

Public Health Relevance

Eleven health systems have joined together to conduct research and to be a large accrue to NCI clinical trials. Our combined programs cover the west half of Michigan to care for almost 9,000 newly diagnosed cancer patients and their families per year. CRCWM is ideally positioned both structurally and in patient diversity to contribute to the NCI NCORP research initiatives.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
3UG1CA189860-01S1
Application #
8927724
Study Section
Special Emphasis Panel (ZCA1-RTRB-E (M1))
Program Officer
Pearson, Deborah
Project Start
2014-08-01
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$50,000
Indirect Cost
$17,533
Name
Spectrum Health Hospitals
Department
Type
DUNS #
047593173
City
Grand Rapids
State
MI
Country
United States
Zip Code
49503
West, Howard L; Moon, James; Wozniak, Antoinette J et al. (2018) Paired Phase II Studies of Erlotinib/Bevacizumab for Advanced Bronchioloalveolar Carcinoma or Never Smokers With Advanced Non-Small-cell Lung Cancer: SWOG S0635 and S0636 Trials. Clin Lung Cancer 19:84-92
Hussain, Maha; Tangen, Catherine M; Thompson Jr, Ian M et al. (2018) Phase III Intergroup Trial of Adjuvant Androgen Deprivation With or Without Mitoxantrone Plus Prednisone in Patients With High-Risk Prostate Cancer After Radical Prostatectomy: SWOG S9921. J Clin Oncol 36:1498-1504
Wagner, Lynne I; Zhao, Fengmin; Goss, Paul E et al. (2018) Patient-reported predictors of early treatment discontinuation: treatment-related symptoms and health-related quality of life among postmenopausal women with primary breast cancer randomized to anastrozole or exemestane on NCIC Clinical Trials Group (CCTG Breast Cancer Res Treat 169:537-548
Persky, Daniel O; Li, Hongli; Rimsza, Lisa M et al. (2018) A phase I/II trial of vorinostat (SAHA) in combination with rituximab-CHOP in patients with newly diagnosed advanced stage diffuse large B-cell lymphoma (DLBCL): SWOG S0806. Am J Hematol 93:486-493
Sekeres, Mikkael A; Othus, Megan; List, Alan F et al. (2017) Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117. J Clin Oncol 35:2745-2753
Danilov, Alexey V; Li, Hongli; Press, Oliver W et al. (2017) Feasibility of interim positron emission tomography (PET)-adapted therapy in HIV-positive patients with advanced Hodgkin lymphoma (HL): a sub-analysis of SWOG S0816 Phase 2 trial. Leuk Lymphoma 58:461-465
Heinrich, Michael C; Rankin, Cathryn; Blanke, Charles D et al. (2017) Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033. JAMA Oncol 3:944-952
Durie, Brian G M; Hoering, Antje; Abidi, Muneer H et al. (2017) Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet 389:519-527
Press, Oliver W; Li, Hongli; Schöder, Heiko et al. (2016) US Intergroup Trial of Response-Adapted Therapy for Stage III to IV Hodgkin Lymphoma Using Early Interim Fluorodeoxyglucose-Positron Emission Tomography Imaging: Southwest Oncology Group S0816. J Clin Oncol 34:2020-7
Till, Brian G; Li, Hongli; Bernstein, Steven H et al. (2016) Phase II trial of R-CHOP plus bortezomib induction therapy followed by bortezomib maintenance for newly diagnosed mantle cell lymphoma: SWOG S0601. Br J Haematol 172:208-18

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